日本血液透析患者丙型肝炎病毒血症的患病率及作用。

Prevalence and role of hepatitis C viraemia in haemodialysis patients in Japan.

作者信息

Hayashi J, Nakashima K, Yoshimura E, Kishihara Y, Ohmiya M, Hirata M, Kashiwagi S

机构信息

Department of General Medicine, Kyushu University Hospital, Fukuoka, Japan.

出版信息

J Infect. 1994 May;28(3):271-7. doi: 10.1016/s0163-4453(94)91743-4.

DOI:10.1016/s0163-4453(94)91743-4

PMID:7522260

Abstract

A second generation assay for antibody to hepatitis C virus (anti-HCV) was used in order to establish the exact prevalence of HCV infection in haemodialysis patients. HCV RNA was sought by the polymerase chain reaction in order to determine whether haemodialysis patients with anti-HCV had been infected with HCV in the past or were presently infected. Of 357 patients, 198 (55.5%) were positive for anti-HCV, compared to 113 (31.7%) positive for original antibody to c100-3 protein (P < 0.001). HCV RNA was detected in 171 (86.4%) of the 198 patients with anti-HCV. Liver dysfunction was found in 63 (17.6%) of all haemodialysis patients. Of these, 55 (87.3%) had HCV infection, one (1.6%) hepatitis B virus infection while, in the remaining seven, the origin was unknown. Thus, in almost all anti-HCV-positive patients, HCV viraemia was present. We conclude that HCV is an important cause of liver disease in haemodialysis patients.

摘要

为确定血液透析患者丙型肝炎病毒（HCV）感染的确切患病率，采用了第二代抗HCV检测方法。通过聚合酶链反应寻找HCV RNA，以确定抗HCV的血液透析患者过去是否感染过HCV或目前是否感染。在357例患者中，198例（55.5%）抗HCV呈阳性，相比之下，113例（31.7%）最初的c100 - 3蛋白抗体呈阳性（P < 0.001）。在198例抗HCV患者中，171例（86.4%）检测到HCV RNA。在所有血液透析患者中，63例（17.6%）发现肝功能障碍。其中，55例（87.3%）有HCV感染，1例（1.6%）有乙型肝炎病毒感染，其余7例病因不明。因此，几乎所有抗HCV阳性患者都存在HCV病毒血症。我们得出结论，HCV是血液透析患者肝病的重要病因。