金钱草中的齐墩果烷型三萜皂苷

Oleanane-type triterpenoid saponins from Lysimachia fortunei Maxim.

作者信息

Zhang Shu-Lin, Yang Zi-Ni, He Cui, Liao Hai-Bing, Wang Heng-Shan, Chen Zhen-Feng, Liang Dong

机构信息

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.

出版信息

Phytochemistry. 2018 Mar;147:140-146. doi: 10.1016/j.phytochem.2017.12.022. Epub 2018 Jan 8.

DOI:10.1016/j.phytochem.2017.12.022

PMID:29324278

Abstract

Six previously undescribed oleanane-type triterpenoid saponins, fortunosides A-F, together with six known ones, were isolated from the aerial parts of Lysimachia fortunei Maxim. Their structures were established by spectroscopic data analyses (1D, 2D-NMR and HRESIMS) and chemical methods. All isolated triterpenoid saponins were evaluated for their cytotoxicity against four human liver cancer cell lines (SMMC-7721, Hep3B, HuH7, and SK-Hep-1). Three saponins with the aglycone protoprimulagenin A exhibited moderate cytotoxicity against all of the tested human cancer cell lines, with IC values ranging from 4.76 to 15.12 μM.

摘要

从金钱草（Lysimachia fortunei Maxim.）地上部分分离得到6个新的齐墩果烷型三萜皂苷，fortuneosides A - F，以及6个已知的此类皂苷。通过光谱数据分析（一维、二维核磁共振和高分辨电喷雾电离质谱）和化学方法确定了它们的结构。对所有分离得到的三萜皂苷进行了针对四种人肝癌细胞系（SMMC - 7721、Hep3B、HuH7和SK - Hep - 1）的细胞毒性评估。三种以原报春花皂苷元A为苷元的皂苷对所有测试的人癌细胞系均表现出中等细胞毒性，IC值范围为4.76至15.12 μM。