泛素结合酶 2：使客户相位脱离？
Ubiquilin 2: Shuttling Clients Out of Phase?
机构信息
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Mol Cell. 2018 Mar 15;69(6):919-921. doi: 10.1016/j.molcel.2018.02.030.
Abstract
Ubiquilin 2 (UBQLN2) is an amyotrophic lateral sclerosis-linked molecular chaperone with a prion-like domain that directly engages ubiquitin to triage clients for proteasomal degradation. Dao et al. (2018) now establish that UBQLN2 forms ubiquitin-labile liquids, which may enable UBQLN2 to specifically extract ubiquitylated clients from stress granules for degradation.
摘要
泛素结合酶 2（UBQLN2）是一种与肌萎缩侧索硬化症相关的分子伴侣，具有类朊病毒结构域，可直接与泛素结合，将底物分类为蛋白酶体降解。Dao 等人（2018 年）的研究表明，UBQLN2 可形成不稳定的泛素液滴，这可能使其能够特异性地从应激颗粒中提取泛素化的底物进行降解。
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