Berger Sarah, El Chazli Yassine, Babu Ambrin F, Coste Alix T
Institute of Microbiology, University Hospital Center, University of LausanneLausanne, Switzerland.
Front Microbiol. 2017 Jun 7;8:1024. doi: 10.3389/fmicb.2017.01024. eCollection 2017.
Agricultural industry uses pesticides to optimize food production for the growing human population. A major issue for crops is fungal phytopathogens, which are treated mainly with azole fungicides. Azoles are also the main medical treatment in the management of diseases caused by ubiquitous fungi, such as . However, epidemiological research demonstrated an increasing prevalence of azole-resistant strains in . The main resistance mechanism is a combination of alterations in the gene (TR34/L98H). Surprisingly, this mutation is not only found in patients receiving long-term azole therapy for chronic aspergillosis but also in azole naïve patients. This suggests an environmental route of resistance through the exposure of azole fungicides in agriculture. In this review, we report data from several studies that strongly suggest that agricultural azoles are responsible for medical treatment failure in azole-naïve patients in clinical settings.
农业产业使用杀虫剂来为不断增长的人口优化粮食生产。农作物面临的一个主要问题是真菌性植物病原体，主要使用唑类杀菌剂进行处理。唑类也是治疗由常见真菌引起的疾病（如……）的主要药物。然而，流行病学研究表明，在……中唑类耐药菌株的流行率在不断上升。主要的耐药机制是基因（TR34/L98H）改变的组合。令人惊讶的是，这种突变不仅在接受长期唑类治疗慢性曲霉病的患者中发现，也在未接触过唑类的患者中发现。这表明通过农业中唑类杀菌剂的暴露存在一种耐药性的环境传播途径。在这篇综述中，我们报告了几项研究的数据，这些数据有力地表明农业用唑类导致了临床环境中未接触过唑类的患者的治疗失败。
