Rodríguez Carlos Hernán, Nastro Marcela, Famiglietti Angela
Hospital de Clínicas José de San Martín, Departamento de Bioquímica Clínica, Córdoba 2351, 1120 Buenos Aires, Argentina.
Hospital de Clínicas José de San Martín, Departamento de Bioquímica Clínica, Córdoba 2351, 1120 Buenos Aires, Argentina.
Rev Argent Microbiol. 2018 Jul-Sep;50(3):327-333. doi: 10.1016/j.ram.2017.10.006. Epub 2018 Mar 13.
Carbapenem resistance in gram-negative bacteria by production of carbapenemases is one of the most challenging issues regarding healthcare worldwide. We review the epidemiology and prevalence of carbapenemases in carbapenem-resistant Acinetobacter baumannii isolates from Latin American countries. High resistance rates to antimicrobial agents, particularly to carbapenems, are observed in this region. OXA-23 is the most widely disseminated class D-carbapenemase; it is present in all the countries of the region and is frequently associated to endemic clones CC113/CC79, CC104/CC15, CC110/ST25 and CC109/CC1. The emergence of OXA-72 and NDM-1 represents a novel finding which is observed simultaneously and without clonal relatedness in different countries, some of which are distant from one another, whereas OXA-143 is only present in Brazil. Further collaborative intraregional studies would provide a better understanding of these issues in most of the countries and thus, policies to control the spread of these isolates could be implemented.
革兰氏阴性菌通过产生碳青霉烯酶而对碳青霉烯类产生耐药性是全球医疗保健领域最具挑战性的问题之一。我们综述了拉丁美洲国家耐碳青霉烯鲍曼不动杆菌分离株中碳青霉烯酶的流行病学和流行情况。该地区观察到对抗菌药物，尤其是对碳青霉烯类的高耐药率。OXA-23是分布最广泛的D类碳青霉烯酶；它存在于该地区所有国家，并且经常与流行克隆CC113/CC79、CC104/CC15、CC110/ST25和CC109/CC1相关。OXA-72和NDM-1的出现是一个新发现，在不同国家同时观察到且无克隆相关性，其中一些国家彼此相距甚远，而OXA-143仅存在于巴西。进一步的区域内合作研究将有助于大多数国家更好地理解这些问题，从而能够实施控制这些分离株传播的政策。
