Department of Regulation in Infection Biology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany; Current address: School of Biological Sciences, University of Wollongong, 2522 Wollongong, Australia; Both authors contributed equally to this work.
Department of Regulation in Infection Biology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany; Both authors contributed equally to this work.
Trends Microbiol. 2018 May;26(5):401-410. doi: 10.1016/j.tim.2018.02.009. Epub 2018 Mar 13.
Both extracellular RNAs and extracellular vesicles (EVs) have recently garnered attention as novel mediators of intercellular communication in eukaryotes and prokaryotes alike. EVs not only permit export of RNA, but also facilitate delivery and trans-kingdom exchange of these and other biomolecules, for instance between microbes and their hosts. In this Opinion article, we propose that EV-mediated export of RNA represents a universal mechanism for interkingdom and intrakingdom communication that is conserved among bacterial, archaeal, and eukaryotic microbes. We speculate how microbes might use EV RNA to influence target cell gene expression or manipulate host immune responses.
细胞外 RNA 和细胞外囊泡（EVs）最近作为真核生物和原核生物中细胞间通讯的新型介质引起了关注。EVs 不仅允许 RNA 的输出，而且还促进这些和其他生物分子的递呈和跨界交换，例如在微生物与其宿主之间。在这篇观点文章中，我们提出 EV 介导的 RNA 输出代表了一种在细菌、古菌和真核微生物中保守的跨界和种内通讯的通用机制。我们推测微生物如何利用 EV RNA 来影响靶细胞基因表达或操纵宿主免疫反应。
