Knowledge and Performance Department, Advanced Research, L'Oréal Research and Innovation, 93600, Aulnay-sous-Bois, France.
Scientific Directorate, L'Oréal Research and Innovation, 92100, Clichy, France.
Mech Ageing Dev. 2019 Jan;177:150-156. doi: 10.1016/j.mad.2018.03.006. Epub 2018 Mar 13.
Ageing is today a major societal concern that is intrinsically associated with the increase of life expectancy. Outside the context of severe degenerative diseases that affect the elderly populations, normal visible signs of ageing, notably skin sagging and wrinkles, influence the social and individual perception of peoples. Accordingly, there is a strong demand for researches on skin ageing. Deciphering the cellular and molecular processes of skin evolution through ageing is thus an active scientific domain, at the frontier of tissue developmental and ageing biology. The focus of the present article is to provide an overview of the current knowledge concerning the evolution of dermis characteristics at different life stages, from intra-uterine to post-natal life. The description will integrate stage-specific and age-related changes in dermis characteristics at the tissue, cell, and molecular levels.
衰老是当今社会的一个主要关注点，它与预期寿命的延长密切相关。除了影响老年人群体的严重退行性疾病之外，正常的衰老可见迹象，特别是皮肤松弛和皱纹，影响着人们的社会和个人认知。因此，人们对皮肤衰老的研究需求很大。因此，通过衰老来破译皮肤进化的细胞和分子过程是一个活跃的科学领域，处于组织发育和衰老生物学的前沿。本文的重点是概述不同生命阶段（从宫内到产后）真皮特征演变的现有知识。描述将整合组织、细胞和分子水平上的真皮特征在特定阶段和年龄相关的变化。
