Anti-Obesity Effects of a Mixture of Fermented Ginseng, BORI, and CH88 in High-Fat Diet-Fed Mice.

Ginseng and probiotics have anti-obesity effects in mice fed a high-fat diet (HFD). Absorption of ginsenoside and colonization of probiotics occur in the intestine. In this study, a mixture of fermented ginseng and two probiotics, BORI and CH88, was administered to HFD-fed mice for 9 weeks. The mixture significantly suppressed weight gain ( < 0.05, = 8) and lipid deposition in the liver and adipose tissues as well as increased the mice's food intake. The adipocyte size of the adipose tissue was significantly decreased in the mixture-fed group, especially when 0.5% fermented ginseng and 5 × 10⁸/ml of the two probiotics were used ( < 0.05, = 10). The expression of TNF-α in adipose tissue was efficiently downregulated in the mixture-fed group ( < 0.05, = 4). The supplement also improved the mice's fasting blood glucose levels ( < 0.05, = 8) and total cholesterol feces excretion ( < 0.05, = 8). The mixture of fermented ginseng and BORI and CH88 could have an anti-obesity effect and suppress lipid deposit in the liver and adipose tissues.