Tai Xueyue, Li Jiating, Song Jianwei, Zhong Bao, Li Fenglin
College of Food Science and Nutritional Engineering, Jilin Agriculture Science and Technology University, Jilin, China.
College of Food Science and Engineering, Changchun University, Changchun, China.
Food Nutr Res. 2025 May 8;69. doi: 10.29219/fnr.v69.12230. eCollection 2025.
Administration of high-dose fermented ginseng powder (2.385 mg/g) resulted in a reduction in body weight and an improvement in blood biochemical parameters in high-fat diet (HFD)-fed mice. Significant reductions in lipid droplet size were observed in both liver and epididymal adipose tissues. Western blot analysis showed increased protein levels of PPAR-α, PPAR-γ, and PGC-1 in the HFD + low-dose lyophilized fermented ginseng powder (HDL), HFD + medium-dose lyophilized fermented ginseng powder (HDM), and HFD + high-dose lyophilized fermented ginseng powder (HDH) groups compared to the HD group. Furthermore, the phosphorylation of AMPK (P-AMPK) and ACC (P-ACC) was significantly elevated. Conversely, western blot analysis demonstrated a decrease in the expression of inflammatory cytokines IL-1, IL-6, and TNF-α in the CG, HDL, HDM, and HDH groups compared to the HD group. Gene expression analysis revealed a downregulation of lipid anabolism-related genes, including and , along with an upregulation of and mRNA levels. Additionally, the expression of inflammation-related genes such as , , and was reduced. High-dose freeze-dried fermented ginseng powder (2.385 mg/g) significantly influenced lipid metabolism and inflammatory responses, highlighting its potential as a therapeutic agent for the management of dyslipidemia.
给予高脂饮食（HFD）喂养的小鼠高剂量发酵人参粉（2.385毫克/克）可导致体重减轻，并改善血液生化参数。在肝脏和附睾脂肪组织中均观察到脂滴大小显著减小。蛋白质印迹分析显示，与高脂饮食组（HD）相比，高脂饮食+低剂量冻干发酵人参粉（HDL）组、高脂饮食+中剂量冻干发酵人参粉（HDM）组和高脂饮食+高剂量冻干发酵人参粉（HDH）组中PPAR-α、PPAR-γ和PGC-1的蛋白质水平升高。此外，AMPK（P-AMPK）和ACC（P-ACC）的磷酸化显著升高。相反，蛋白质印迹分析表明，与HD组相比，普通人参组（CG）、HDL组、HDM组和HDH组中炎症细胞因子IL-1、IL-6和TNF-α的表达降低。基因表达分析显示，包括 和 在内的脂质合成相关基因下调，同时 和 的mRNA水平上调。此外， 、 和 等炎症相关基因的表达降低。高剂量冻干发酵人参粉（2.385毫克/克）显著影响脂质代谢和炎症反应，突出了其作为治疗血脂异常药物的潜力。
