肿瘤坏死因子α在胃癌突变前后的作用。
Function of tumor necrosis factor alpha before and after mutation in gastric cancer.
作者信息
Zhang Xia, Wang Jianjun, Shao Huanzhang, Zhu Wenliang
机构信息
Intensive Care Unit, Henan Provincial People's Hospital, Zhengzhou 450000, PR China.
Department of Oncology, Henan University Huaihe Hospital, Kaifeng 475001, PR China.
出版信息
Saudi J Biol Sci. 2017 Dec;24(8):1920-1924. doi: 10.1016/j.sjbs.2017.11.040. Epub 2017 Nov 23.
PURPOSE
To explore the cause of functional changes of tumor necrosis factor alpha (TNF-α) in development of gastric cancer through the structural changes of each site in TNF-α before and after mutation.
METHODS
Three typical mutant sites (TNF-α-308G/A, 857C/T and 863C/A of TNF-α) were chosen and methods like ab initio modeling was adopted for 3D modeling of TNF-α before and after mutation, besides, the structural changes were also analyzed.
RESULTS
Mutation of TNF-α-308G/A led to the production of multiple helical structures and that of 863C/A caused the production of one helical structure in its adjacent region. Mutation of 857C/T, however, did not cause the change in the basic structure of TNF-α.
CONCLUSIONS
Structural changes of TNF-α may have a significant effect on development of gastric cancer.
目的
通过肿瘤坏死因子α（TNF-α）突变前后各位点的结构变化，探讨胃癌发生发展过程中TNF-α功能改变的原因。
方法
选取三个典型突变位点（TNF-α的-308G/A、857C/T和863C/A），采用从头建模等方法对TNF-α突变前后进行三维建模，并分析其结构变化。
结果
TNF-α-308G/A突变导致多个螺旋结构产生，863C/A突变使其相邻区域产生一个螺旋结构，而857C/T突变未引起TNF-α基本结构的改变。
结论
TNF-α的结构变化可能对胃癌的发生发展产生显著影响。
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