提取物中槲皮素糖苷对肝癌细胞系HepG2、前列腺癌细胞系PC-3和结肠癌细胞系HT-29的影响。
Effect of quercetin glucosides from extracts on HepG2, PC-3 and HT-29 cancer cell lines.
作者信息
Pan Yingkun, Zheng Yi Mei, Ho Wing Shing
机构信息
School of Life Sciences, The Chinese University of Hong Kong, Shatin, 011-852 Hong Kong, SAR, P.R. China.
Minnan Normal University, College of Biological Science and Technology, Zhangzhou, Fujian 363000, P.R. China.
出版信息
Oncol Lett. 2018 Apr;15(4):4657-4661. doi: 10.3892/ol.2018.7893. Epub 2018 Jan 29.
Abstract
The present study investigated the effects of quercetin glucosides, which were isolated from the Chinese onion (), garlic (), onion ( L.) and the Welsh onion ( L.) in HepG2, HT-29 and PC-3 cancer cell lines. Quercetin-3,4'-di-O-glucoside (3,4'-Qdg) and quercetin-4'-O-glucoside (4'-Qmg) comprise ~98% of the flavonoids in the methanol extract of onion. A small amount of 3,4'-Qdg is present in the Welsh onion and Chinese onion, whereas 4'-Qmg is also present in the Welsh onion. In HepG2 cells, 4'-Qmg was demonstrated to exhibit more significant growth inhibition compared with 3,4'-Qdg and quercetin 3-β-D-glucoside, but exhibited less inhibitory effects in PC-3 and HT-29 cells. These results suggest the anti-proliferative potential of 4'-Qmg in various cancer cell lines and the health benefits of the genus . The findings indicate the potential of 4'-Qmg as an anticancer agent for further development.
摘要
本研究调查了从大葱（）、大蒜（）、洋葱（L.）和葱（L.）中分离出的槲皮素糖苷对HepG2、HT - 29和PC - 3癌细胞系的影响。槲皮素 - 3,4'-二 - O - 葡萄糖苷（3,4'-Qdg）和槲皮素 - 4'-O - 葡萄糖苷（4'-Qmg）占洋葱甲醇提取物中黄酮类化合物的约98%。大葱和洋葱中存在少量的3,4'-Qdg，而葱中也存在4'-Qmg。在HepG2细胞中，与3,4'-Qdg和槲皮素3 - β - D - 葡萄糖苷相比，4'-Qmg表现出更显著的生长抑制作用，但在PC - 3和HT - 29细胞中的抑制作用较小。这些结果表明4'-Qmg在各种癌细胞系中的抗增殖潜力以及该属植物的健康益处。研究结果表明4'-Qmg作为一种抗癌剂具有进一步开发的潜力。
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