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Quercetin-3-O-β-D-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells.从菥蓂中分离得到的槲皮素-3-O-β-D-葡萄糖醛酸苷可抑制人原代细胞衰老。
Arch Pharm Res. 2014;37(9):1219-33. doi: 10.1007/s12272-014-0344-2. Epub 2014 Mar 18.
2
Quercetin-rich onion peel extract suppresses adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 adipocytes.富含槲皮素的洋葱皮提取物通过下调3T3-L1脂肪细胞中脂肪生成转录因子和基因表达来抑制脂肪生成。
J Sci Food Agric. 2014 Oct;94(13):2655-60. doi: 10.1002/jsfa.6604. Epub 2014 Mar 14.
3
Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1.秀丽莓醇提物及其活性成分槲皮素通过靶向 Syk/Src/IRAK-1 抑制 LPS 诱导的巨噬细胞活化和腹膜炎。
J Ethnopharmacol. 2014 Feb 12;151(3):1165-1174. doi: 10.1016/j.jep.2013.12.033. Epub 2013 Dec 27.
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Activity of flavonoids and β-carotene during the auto-oxidative deterioration of model food oil-in water emulsions.类黄酮和β-胡萝卜素在模型油水乳液自动氧化劣化过程中的活性。
Food Chem. 2014 May 1;150:280-6. doi: 10.1016/j.foodchem.2013.10.112. Epub 2013 Nov 1.
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Quercetin-induced cardioprotection against doxorubicin cytotoxicity.槲皮素对抗阿霉素细胞毒性的心脏保护作用。
J Biomed Sci. 2013 Dec 20;20(1):95. doi: 10.1186/1423-0127-20-95.
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Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling.槲皮素具有抗黑色素瘤活性，并抑制 STAT3 信号通路。
Biochem Pharmacol. 2014 Feb 1;87(3):424-34. doi: 10.1016/j.bcp.2013.11.008. Epub 2013 Nov 23.
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The therapeutic potential and mechanisms of action of quercetin in relation to lipopolysaccharide-induced sepsis in vitro and in vivo.槲皮素在体外和体内对脂多糖诱导的败血症的治疗潜力及作用机制。
PLoS One. 2013 Nov 19;8(11):e80744. doi: 10.1371/journal.pone.0080744. eCollection 2013.
8
Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a.槲皮素和金丝桃苷的组合通过抑制致癌 microRNA-27a 对肾癌细胞发挥抗癌作用。
Oncol Rep. 2014 Jan;31(1):117-24. doi: 10.3892/or.2013.2811. Epub 2013 Oct 24.
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Novel quercetin derivatives in treatment of peroxynitrite-oxidized SERCA1.新型槲皮素衍生物治疗过氧亚硝基氧化 SERCA1。
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10
Production of quercetin, kaempferol and their glycosidic derivatives from the aqueous-organic extracted residue of litchi pericarp with Aspergillus awamori.用米曲霉从荔枝果皮的水-有机溶剂提取残渣中生产槲皮素、山奈酚及其糖苷衍生物。
Food Chem. 2014 Feb 15;145:220-7. doi: 10.1016/j.foodchem.2013.08.048. Epub 2013 Aug 22.

提取物中槲皮素糖苷对肝癌细胞系HepG2、前列腺癌细胞系PC-3和结肠癌细胞系HT-29的影响。

Effect of quercetin glucosides from extracts on HepG2, PC-3 and HT-29 cancer cell lines.

作者信息

Pan Yingkun, Zheng Yi Mei, Ho Wing Shing

机构信息

School of Life Sciences, The Chinese University of Hong Kong, Shatin, 011-852 Hong Kong, SAR, P.R. China.

Minnan Normal University, College of Biological Science and Technology, Zhangzhou, Fujian 363000, P.R. China.

出版信息

Oncol Lett. 2018 Apr;15(4):4657-4661. doi: 10.3892/ol.2018.7893. Epub 2018 Jan 29.

DOI:10.3892/ol.2018.7893
PMID:29552109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5840711/
Abstract

The present study investigated the effects of quercetin glucosides, which were isolated from the Chinese onion (), garlic (), onion ( L.) and the Welsh onion ( L.) in HepG2, HT-29 and PC-3 cancer cell lines. Quercetin-3,4'-di-O-glucoside (3,4'-Qdg) and quercetin-4'-O-glucoside (4'-Qmg) comprise ~98% of the flavonoids in the methanol extract of onion. A small amount of 3,4'-Qdg is present in the Welsh onion and Chinese onion, whereas 4'-Qmg is also present in the Welsh onion. In HepG2 cells, 4'-Qmg was demonstrated to exhibit more significant growth inhibition compared with 3,4'-Qdg and quercetin 3-β-D-glucoside, but exhibited less inhibitory effects in PC-3 and HT-29 cells. These results suggest the anti-proliferative potential of 4'-Qmg in various cancer cell lines and the health benefits of the genus . The findings indicate the potential of 4'-Qmg as an anticancer agent for further development.

摘要

本研究调查了从大葱（）、大蒜（）、洋葱（L.）和葱（L.）中分离出的槲皮素糖苷对HepG2、HT - 29和PC - 3癌细胞系的影响。槲皮素 - 3,4'-二 - O - 葡萄糖苷（3,4'-Qdg）和槲皮素 - 4'-O - 葡萄糖苷（4'-Qmg）占洋葱甲醇提取物中黄酮类化合物的约98%。大葱和洋葱中存在少量的3,4'-Qdg，而葱中也存在4'-Qmg。在HepG2细胞中，与3,4'-Qdg和槲皮素3 - β - D - 葡萄糖苷相比，4'-Qmg表现出更显著的生长抑制作用，但在PC - 3和HT - 29细胞中的抑制作用较小。这些结果表明4'-Qmg在各种癌细胞系中的抗增殖潜力以及该属植物的健康益处。研究结果表明4'-Qmg作为一种抗癌剂具有进一步开发的潜力。