Biological Sciences Department, College of Science, King Faisal University, Al Ahsa 31982, Saudi Arabia.
Central Laboratory, Theodor Bilharz Research Institute, Giza 12411, Egypt.
Nutrients. 2023 Feb 28;15(5):1206. doi: 10.3390/nu15051206.
Schistosomiasis is a tropical disease caused by trematode worms. The inflammatory response of the host to schistosome eggs leads to formation of granuloma in the liver and intestine. Praziquantel (PZQ) is still an effective treatment for schistosomiasis, however resistance development may reduce its efficacy. The current study investigated the possible immunomodulatory and anti-inflammatory action of rutin, a natural flavonoid compound isolated from garlic, on liver fibrotic markers in mice infected with in comparison to PZQ. Male albino CD1 mice were infected with 100 ± 2 cercariae/mouse and treated with garlic, rutin, or PZQ. At the end of the experiment, the liver and intestines were harvested for parasitological and histological assessment and to analyze the proinflammatory cytokine. Rutin significantly affects the pathological alterations caused by in the liver. This may be partially explained by a decrease in the number of eggs trapped in the tissues of the liver and a modification in the serum levels of certain cytokines, which are implicated in the formation of granuloma. In conclusion, rutin has strong anti-schistosome properties in vivo, raising the possibility that rutin might be further investigated as a therapy for .
血吸虫病是一种由吸虫引起的热带疾病。宿主对血吸虫卵的炎症反应导致肝脏和肠道中肉芽肿的形成。吡喹酮（PZQ）仍然是治疗血吸虫病的有效药物，然而耐药性的发展可能会降低其疗效。本研究旨在探讨天然类黄酮化合物芦丁（从大蒜中分离得到）对感染 的小鼠肝纤维化标志物的可能免疫调节和抗炎作用，并与 PZQ 进行比较。雄性白化 CD1 小鼠经 100±2 尾蚴/只感染后，用大蒜、芦丁或 PZQ 进行治疗。实验结束时，采集肝脏和肠道进行寄生虫学和组织学评估，并分析促炎细胞因子。芦丁显著影响 在肝脏引起的病理改变。这可能部分解释为组织中被困的虫卵数量减少，以及某些细胞因子的血清水平发生改变，这些细胞因子与 肉芽肿的形成有关。总之，芦丁在体内具有很强的抗血吸虫作用，这使得芦丁有可能进一步被研究作为 的治疗方法。
