Bi Laixi, Sun Lan, Jin Zhenlin, Zhang Shenghui, Shen Zhijian
Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Oncol Lett. 2018 Apr;15(4):5611-5619. doi: 10.3892/ol.2018.8050. Epub 2018 Feb 14.
MicroRNAs (miRs) have been demonstrated to perform important roles in normal hematopoiesis and leukemogenesis. Accumulating evidence suggests that miR-10a and miR-10b may behave as novel oncogenes or tumor suppressors in human cancer. The present study reported the function of the miR-10 family in myeloid differentiation and acute myeloid leukemia (AML). The levels of miR-10a/b expression were increased in AML cases compared with normal controls, particularly in M1, M2 and M3 subtypes. The levels of miR-10a/b expression were also upregulated in patients with nucleophosmin-mutated AML and AML patients with t(8;21) and t(9;11), compared with the normal control. In addition, the role of miR-10a/b in regulating myeloid differentiation and leukemogenesis was investigated. The results indicated that miR-10a/b expression was able to promote the proliferation of human promyelocytic leukemia cells, while suppressing the granulocytic and monocytic differentiation of the leukemia cells. These findings suggested that abnormal high expression of miR-10a/b may result in unlimited proliferation of immature blood progenitors and repression of mature blood cell differentiation and maturation, thus leading to the occurrence of AML. miR-10a/b may be developed as novel therapeutic targets for the treatment of AML.
微小RNA（miR）已被证明在正常造血和白血病发生过程中发挥重要作用。越来越多的证据表明，miR-10a和miR-10b在人类癌症中可能作为新的癌基因或肿瘤抑制因子发挥作用。本研究报道了miR-10家族在髓系分化和急性髓系白血病（AML）中的功能。与正常对照组相比，AML病例中miR-10a/b的表达水平升高，尤其是在M1、M2和M3亚型中。与正常对照组相比，核磷蛋白突变的AML患者以及伴有t(8;21)和t(9;11)的AML患者中miR-10a/b的表达水平也上调。此外，还研究了miR-10a/b在调节髓系分化和白血病发生中的作用。结果表明，miR-10a/b的表达能够促进人早幼粒细胞白血病细胞的增殖，同时抑制白血病细胞的粒细胞和单核细胞分化。这些发现提示，miR-10a/b的异常高表达可能导致未成熟血液祖细胞的无限增殖以及成熟血细胞分化和成熟的抑制，从而导致AML的发生。miR-10a/b可能被开发为治疗AML新型治疗靶点。
