高致病性 H7N9 流感病毒在人类中的增强复制。
Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans.
出版信息
Emerg Infect Dis. 2018 Apr;24(4):746-750. doi: 10.3201/eid2404.171509.
Abstract
To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.
摘要
为了阐明高致病性 H7N9 流感病毒感染对人类构成的威胁，我们对病毒聚合酶复合物进行了特征描述。聚合酶碱性 2-482R、聚合酶碱性 2-588V 和聚合酶酸性 497R 单独或联合增强了病毒聚合酶的活性，这表明在 1 个分离株中存在多种复制增强突变可能有助于病毒的毒力。
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