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中国 H4 禽流感病毒的跨种传播潜力：流行病学和进化研究。

Cross-Species Transmission Potential of H4 Avian Influenza Viruses in China: Epidemiological and Evolutionary Study.

机构信息

School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China.

School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou 510006, China.

出版信息

Viruses. 2024 Feb 24;16(3):353. doi: 10.3390/v16030353.

DOI:10.3390/v16030353
PMID:38543719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10974465/
Abstract

H4 avian influenza viruses (AIVs) have been widely detected in live poultry markets in China. However, the potential public health impact of H4 AIVs remains largely uncertain. Here, we fully analyzed the distribution and phylogenetic relationship of H4 AIVs in China. We obtained 31 isolates of H4 viruses in China during 2009-2022 through surveillance in poultry-associated environments, such as live poultry markets and poultry farms. Genomic sequence analysis together with publicly available data revealed that frequent reassortment and introduction of H4 AIV from wild birds to poultry may have occurred. We identified 62 genotypes among 127 whole genome sequences of H4 viruses in China, indicating that H4 AIVs had great genetic diversity in China. We also investigated molecular markers and found that drug resistance mutations frequently occurred in the M2 protein and a few mutations related to receptor binding and the host signature in H4 AIVs. Our study demonstrates the cross-species transmission potential of H4 AIVs in China and provides some reference significance for its risk assessment.

摘要

在中国的活禽市场中已广泛检测到 H4 禽流感病毒（AIVs）。然而，H4 AIV 对公众健康的潜在影响在很大程度上仍不确定。在这里，我们全面分析了中国 H4 AIV 的分布和系统发育关系。通过对活禽市场和家禽养殖场等与家禽相关环境的监测，我们在 2009 年至 2022 年期间在中国获得了 31 株 H4 病毒分离株。基因组序列分析结合公开数据表明，H4 AIV 可能频繁地从野鸟重组和传入家禽。我们在中国的 127 株 H4 病毒全基因组序列中鉴定出 62 种基因型，表明 H4 AIV 在中国具有很大的遗传多样性。我们还调查了分子标记，发现 M2 蛋白中的耐药性突变和 H4 AIV 中与受体结合和宿主特征相关的少数突变经常发生。我们的研究表明 H4 AIV 在我国具有跨物种传播的潜力，并为其风险评估提供了一定的参考意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac22/10974465/d9fcee3fa89f/viruses-16-00353-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac22/10974465/8e05473b9c02/viruses-16-00353-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac22/10974465/f8807223d4c5/viruses-16-00353-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac22/10974465/f6071c87d62d/viruses-16-00353-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac22/10974465/d9fcee3fa89f/viruses-16-00353-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac22/10974465/8e05473b9c02/viruses-16-00353-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac22/10974465/f8807223d4c5/viruses-16-00353-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac22/10974465/f6071c87d62d/viruses-16-00353-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac22/10974465/d9fcee3fa89f/viruses-16-00353-g004.jpg

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Poult Sci. 2023 Oct;102(10):102948. doi: 10.1016/j.psj.2023.102948. Epub 2023 Jul 26.
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