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巴西出现基孔肯雅热病毒后的血清流行率。

Seroprevalence of Chikungunya Virus after Its Emergence in Brazil.

出版信息

Emerg Infect Dis. 2018 Apr;24(4):617-624. doi: 10.3201/eid2404.171370.

Abstract

Chikungunya has had a substantial impact on public health because of the magnitude of its epidemics and its highly debilitating symptoms. We estimated the seroprevalence, proportion of symptomatic cases, and proportion of chronic form of disease after introduction of chikungunya virus (CHIKV) in 2 cities in Brazil. We conducted the population-based study through household interviews and serologic surveys during October-December 2015. In Feira de Santana, we conducted a serologic survey of 385 persons; 57.1% were CHIKV-positive. Among them, 32.7% reported symptoms, and 68.1% contracted chronic chikungunya disease. A similar survey in Riachão do Jacuípe included 446 persons; 45.7% were CHIKV-positive, 41.2% reported symptoms, and 75.0% contracted the chronic form. Our data confirm intense CHIKV transmission during the continuing epidemic. Chronic pain developed in a high proportion of patients. We recommend training health professionals in management of chronic pain, which will improve the quality of life of chikungunya-affected persons.

摘要

基孔肯雅热对公共卫生造成了重大影响,因为其流行规模巨大,症状高度致残。我们在巴西的两个城市估计了基孔肯雅病毒(CHIKV)引入后的血清流行率、症状病例比例和疾病慢性形式比例。我们通过家庭访谈和 2015 年 10 月至 12 月期间的血清学调查进行了这项基于人群的研究。在费拉迪圣安娜,我们对 385 人进行了血清学调查;57.1%的人呈 CHIKV 阳性。其中,32.7%的人报告有症状,68.1%的人患有慢性基孔肯雅病。在瑞恰奥·多·雅库伊佩的一项类似调查中,包括 446 人;45.7%的人呈 CHIKV 阳性,41.2%的人报告有症状,75.0%的人患有慢性疾病。我们的数据证实了在持续流行期间 CHIKV 的强烈传播。相当一部分患者出现慢性疼痛。我们建议培训卫生专业人员管理慢性疼痛,这将提高受基孔肯雅热影响的人的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa3d/5875253/221942d2f198/17-1370-F1.jpg

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