心房利钠因子抑制清醒绵羊的血管加压素分泌。

Atrial natriuretic factor inhibits vasopressin secretion in conscious sheep.

作者信息

Lee J, Malvin R L, Claybaugh J R, Huang B S

出版信息

Proc Soc Exp Biol Med. 1987 Jul;185(3):272-6. doi: 10.3181/00379727-185-42544.

Abstract

To test the hypothesis that atrial natriuretic factor (ANF) has a centrally mediated action on body fluid homeostasis, the effects of intracerebroventricularly (ICV) infused ANF on plasma vasopressin (AVP) concentration and urinary water and electrolyte excretion were investigated in euhydrated and water-deprived conscious sheep. ICV ANF decreased plasma AVP concentration and increased urinary free water excretion in euhydrated sheep, with excretion of Na and K unaltered. However, ICV ANF did not affect urinary volume, free water clearance, or excretion of Na and K in dehydrated animals, although plasma AVP concentration was significantly decreased. The relationship between urine volume and plasma AVP concentration was fitted by a power curve: urine volume = 0.79 X [AVP]-0.71; urine volume changes very little as a function of AVP concentration at the higher ranges. Intravenous infusion of the same amount of ANF was without effect on plasma AVP concentration or urinary excretion in both euhydrated and dehydrated animals. Mean arterial pressure was unchanged throughout all experiments. These results are consistent with the hypothesis that central ANF inhibits AVP secretion.

摘要

为了验证心房利钠因子（ANF）对体液平衡具有中枢介导作用这一假说，研究人员在水合正常和缺水的清醒绵羊中，探究了脑室内（ICV）注入ANF对血浆血管加压素（AVP）浓度以及尿水和电解质排泄的影响。在水合正常的绵羊中，ICV注入ANF可降低血浆AVP浓度，并增加尿自由水排泄，而钠和钾的排泄未发生改变。然而，在脱水动物中，尽管血浆AVP浓度显著降低，但ICV注入ANF并未影响尿量、自由水清除率或钠和钾的排泄。尿量与血浆AVP浓度之间的关系符合幂函数曲线：尿量 = 0.79×[AVP]-0.71；在较高范围内，尿量随AVP浓度的变化很小。在水合正常和脱水的动物中，静脉输注等量的ANF对血浆AVP浓度或尿排泄均无影响。在所有实验过程中，平均动脉压均未改变。这些结果与中枢ANF抑制AVP分泌的假说相符。