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前腭成形术与悬雍垂腭瓣置入术治疗轻中度阻塞性睡眠呼吸暂停的比较

Comparison of anterior palatoplasty and uvulopalatal flap placement for treating mild and moderate obstructive sleep apnea.

作者信息

Haytoğlu Süheyl, Arikan Osman Kürşat, Muluk Nuray Bayar, Tuhanioğlu Birgül, Çörtük Mustafa

机构信息

ENT Department, Adana Numune Training and Research Hospital, Kırıkkale University Faculty of Medicine, Birlik Mahallesi, Zirvekent 2. Etap Sitesi, C-3 blok, No: 62/43 06610 Çankaya, Kırıkkale, Turkey.

出版信息

Ear Nose Throat J. 2018 Mar;97(3):69-78. doi: 10.1177/014556131809700321.

Abstract

We prospectively compared the efficacy of anterior palatoplasty and the uvulopalatal flap procedure for the treatment of patients with mild and moderate obstructive sleep apnea syndrome (OSAS). Our study group was made up of 45 patients who had been randomly assigned to undergo one of the two procedures. Palatoplasty was performed on 22 patients-12 men and 10 women, aged 28 to 49 years (mean: 39.2)-and the flap procedure was performed on 23 patients-14 men and 9 women, aged 28 to 56 years (mean: 41.3). Our primary outcomes measure was the difference in pre- and postoperative apnea-hypopnea index (AHI) as determined by polysomnography at 6 months after surgery. Surgical success was observed in 18 of the 22 palatoplasty patients (81.8%) and in 19 of the 23 flap patients (82.6%). Compared with the preoperative values, mean AHIs declined from 17.5 to 8.1 in the former group and from 18.5 to 8.6 in the latter; the improvement in both groups was statistically significant (p < 0.001). In addition, significant postoperative improvements in both groups were seen in mean visual analog scale (VAS) scores for snoring, in Pittsburgh Sleep Quality Index values, and in Epworth Sleepiness Scale scores (p < 0.001 for all). VAS scores for pain at rest were significantly lower in the palatoplasty group than in the flap group at 2, 4, and 8 hours postoperatively and on postoperative days 4 through 7 (p < 0.002). Likewise, VAS scores for pain during swallowing were significantly lower in the palatoplasty group at 2, 4, 8, and 16 hours and on days 4 through 7 (p < 0.009). We conclude that both anterior palatoplasty and uvulopalatal flap procedures are effective for the treatment of mild and moderate OSAS in patients with retropalatal obstruction. However, our comparison of postoperative pain scores revealed that anterior palatoplasty was associated with significantly less morbidity.

摘要

我们前瞻性地比较了前腭成形术和悬雍垂腭瓣手术治疗轻度和中度阻塞性睡眠呼吸暂停综合征(OSAS)患者的疗效。我们的研究组由45例患者组成,他们被随机分配接受两种手术中的一种。22例患者接受了腭成形术,其中男性12例,女性10例,年龄在28至49岁之间(平均39.2岁);23例患者接受了瓣手术,其中男性14例,女性9例,年龄在28至56岁之间(平均41.3岁)。我们的主要结局指标是术后6个月通过多导睡眠图测定的术前和术后呼吸暂停低通气指数(AHI)的差异。22例腭成形术患者中有18例(81.8%)观察到手术成功,23例瓣手术患者中有19例(82.6%)观察到手术成功。与术前值相比,前一组的平均AHI从17.5降至8.1,后一组从18.5降至8.6;两组的改善均具有统计学意义(p<0.001)。此外,两组术后在打鼾的平均视觉模拟量表(VAS)评分、匹兹堡睡眠质量指数值和爱泼华嗜睡量表评分方面均有显著改善(所有p<0.001)。术后2、4和8小时以及术后第4至7天,腭成形术组静息时疼痛的VAS评分显著低于瓣手术组(p<0.002)。同样,腭成形术组在术后2、4、8和16小时以及第4至7天吞咽时疼痛的VAS评分显著较低(p<0.009)。我们得出结论,前腭成形术和悬雍垂腭瓣手术对于治疗腭后阻塞的轻度和中度OSAS患者均有效。然而,我们对术后疼痛评分的比较显示,前腭成形术的发病率显著较低。

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