膜相关淀粉样蛋白聚集的分子机制：计算视角与挑战
Molecular mechanisms of membrane-associated amyloid aggregation: Computational perspective and challenges.
作者信息
Press-Sandler Olga, Miller Yifat
机构信息
Department of Chemistry, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel; The Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel.
Department of Chemistry, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel; The Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel.
出版信息
Biochim Biophys Acta Biomembr. 2018 Sep;1860(9):1889-1905. doi: 10.1016/j.bbamem.2018.03.014. Epub 2018 Mar 17.
Amyloidogenic proteins are related to a variety of amyloid diseases, such as type 2 diabetes (T2D), Alzheimer's disease (AD) and Parkinson's disease (PD). The amyloid proteins in which this review focuses include amylin, Aβ, tau and α-synuclein. Understanding the molecular mechanisms in which these amyloidogenic proteins interact with membranes is a challenging research to both experimental and computational studies. This review illustrates recent studies on amyloid-membrane interactions, but it mainly focuses on the challenge issues related to experimental techniques to investigate at the molecular level these interactions and provides thoughts and outlook for future computational studies.
淀粉样蛋白与多种淀粉样疾病有关，如2型糖尿病（T2D）、阿尔茨海默病（AD）和帕金森病（PD）。本综述重点关注的淀粉样蛋白包括胰岛淀粉样多肽、β-淀粉样蛋白、tau蛋白和α-突触核蛋白。了解这些淀粉样蛋白与膜相互作用的分子机制，对实验研究和计算研究来说都是一项具有挑战性的工作。本综述阐述了近期关于淀粉样蛋白与膜相互作用的研究，但主要聚焦于在分子水平研究这些相互作用的实验技术相关的挑战性问题，并为未来的计算研究提供思路和展望。
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