Chung Ill-Min, Park Sung-Kyu, Ali Mohd, Prabakaran Mayakrishnan, Oh Young-Tek, Kim Seung-Hyun, Siddiqui Nasir Ali, Ahmad Ateeque
Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, South Korea.
Department of Pharmacognosy and Phytochemistry, Hamdard University, New Delhi 110062, India.
Saudi Pharm J. 2018 Mar;26(3):375-387. doi: 10.1016/j.jsps.2018.01.003. Epub 2018 Jan 12.
Five new flavonoids namely, 5-hydroxy-6-isoprenyl-7,4'-dimethoxyflavonol-3---d-arabinofuranoside (), 5,7-dihydroxy-4'-methoxyflavone-7---d-arabinopyranosyl-2''--decan-1'''-oate (), 3-butanoyl-5,6,8-trihydroxy-7,4'-dimethoxyflavonol--5---d-glucopyranoside (), 7, 4'-dimethoxy-5-hydroxyflavone-5---d-arabinopyranosyl-(2'' → 1''')---d-arabinopyranoside (), and 5,6-dihydroxy-7, 4'-dimethoxyflavone-5---d-glucopyranoside (), together with two known compounds, were isolated from the methanol extract of leaves and straw. Their structures of new compounds were elucidated by 1D and 2D NMR spectral methods, viz: COSY, HMBC and HSQC aided by mass techniques and IR spectroscopy. The cytotoxicity of these compounds (- were assessed by using (RAW 264.7) mouse macrophages cell line, and allelopathic effects of compounds (- on the germination characteristics of barnyardgrass () and pigweed ( L.) were also evaluated. The compounds , and showed cytotoxicity and compounds - exhibited significant inhibitory activity on the seed germination of two weed species.
从叶子和秸秆的甲醇提取物中分离出五种新的黄酮类化合物，即5-羟基-6-异戊烯基-7,4'-二甲氧基黄酮醇-3---d-阿拉伯呋喃糖苷（）、5,7-二羟基-4'-甲氧基黄酮-7---d-阿拉伯吡喃糖基-2''--癸酸-1'''-酯（）、3-丁酰基-5,6,8-三羟基-7,4'-二甲氧基黄酮醇--5---d-葡萄糖吡喃糖苷（）、7,4'-二甲氧基-5-羟基黄酮-5---d-阿拉伯吡喃糖基-(2'' → 1''')---d-阿拉伯吡喃糖苷（）和5,6-二羟基-7,4'-二甲氧基黄酮-5---d-葡萄糖吡喃糖苷（），以及两种已知化合物。通过一维和二维核磁共振光谱方法，即：COSY、HMBC和HSQC，并借助质谱技术和红外光谱对新化合物的结构进行了阐明。使用（RAW 264.7）小鼠巨噬细胞系评估了这些化合物（-的细胞毒性，并评估了化合物（-对稗草（）和藜（L.）种子萌发特性的化感作用。化合物、和表现出细胞毒性，化合物-对两种杂草种子的萌发表现出显著的抑制活性。
