Dorchy H, Toussaint D, Vanderschueren-Lodeweyckx M, Vandenbussche E, De Vroede M, Loeb H
Acta Paediatr Scand Suppl. 1979;277:47-53. doi: 10.1111/j.1651-2227.1979.tb06191.x.
In order to ascertain the first vascular lesions responsible for juvenile diabetic retinopathy, 408 fluorescein angiographies were performed in 114 diabetic children and adolescents whose diabetes became clinically apparent before the age of 14 years. Compared with regular ophthalmoscopy, fluorescein angiography doubles the frequency of the diagnosis of incipient retinopathy. In addition to the classical diabetic lesions, fluorescein leakages are demonstrated in 50% of diabetic eyes with initial retinopathy. They probably reflect early changes in capillary permeability. They appear often before microaneurysms. Duration of diabetes as well as insufficient and poor metabolic control considerably increase the frequency of retinopathy.
为了确定导致青少年糖尿病视网膜病变的首批血管病变，对114例糖尿病患儿及青少年进行了408次荧光素血管造影，这些患儿及青少年在14岁之前糖尿病临床表现明显。与常规检眼镜检查相比，荧光素血管造影使早期视网膜病变的诊断频率翻倍。除了典型的糖尿病病变外，50%的初发视网膜病变糖尿病眼显示有荧光素渗漏。它们可能反映了毛细血管通透性的早期变化。它们常出现在微动脉瘤之前。糖尿病病程以及代谢控制不足和不佳会显著增加视网膜病变的发生率。
