Tiradentes University, Av. Murilo Dantas, 300, Farolândia, Aracaju, SE, 49032-490, Brazil.
Federal University of Pará, Alameda Leandro Ribeiro, s/n, Aldeia, Bragança, PA, 68600-000, Brazil.
Environ Sci Pollut Res Int. 2018 May;25(15):15102-15110. doi: 10.1007/s11356-018-1622-1. Epub 2018 Mar 20.
Deltamethrin is one of the most commonly used pyrethroids in the world, and it has a high toxic potential, mainly on aquatic organism. Thus, the purpose of this study was to evaluate LC values of deltamethrin on tambaqui (Colossoma macropomum) fingerlings and to investigate genotoxic effects and histopathological responses. Fish were exposed to different concentrations of deltamethrin (0, 6.16 × 10; 6.44 × 10; 1.34 × 10, and 1.93 × 10 mg L) for 96 h. In addition, a genotoxicity analysis was carried out on peripheral blood erythrocytes and histopathological changes were classified by the severity degree of damage and organ functioning. The 96 h LC value for tambaqui was estimated at 5.56 × 10 mg L using a static test system. Nuclear abnormalities in exposed fish included micronuclei, blebbed, notched, 8-shaped, and binucleated nuclei forms. Deltamethrin significantly induced a notched nucleus compared to other abnormalities. A histopathological examination showed hepatic lesions and gill damage. Deltamethrin was found to be highly toxic; it induced genotoxicity and caused liver and gill inflammation in tambaqui.
溴氰菊酯是世界上使用最广泛的拟除虫菊酯之一，具有很高的毒性潜力，主要对水生生物。因此，本研究旨在评估溴氰菊酯对淡水鳕鱼（Colossoma macropomum）鱼苗的 LC 值，并研究其遗传毒性效应和组织病理学反应。鱼被暴露在不同浓度的溴氰菊酯（0、6.16×10；6.44×10；1.34×10 和 1.93×10 mg L）中 96 小时。此外，还对外周血红细胞进行了遗传毒性分析，并根据损伤和器官功能的严重程度对组织病理学变化进行了分类。使用静态测试系统，估计溴氰菊酯对淡水鳕鱼的 96 小时 LC 值为 5.56×10 mg L。暴露于溴氰菊酯的鱼的核异常包括微核、泡状、缺口、8 字形和双核核形式。与其他异常相比，溴氰菊酯显著诱导了缺口核。组织病理学检查显示肝脏病变和鳃损伤。溴氰菊酯具有高毒性，它在淡水鳕鱼中诱导遗传毒性，并导致肝脏和鳃炎症。
