[Oligometastasis in pancreatic cancer : Current state of knowledge and spectrum of local therapy].

BACKGROUND

Several case series reported results of surgical resection in patients with pancreatic ductal adenocarcinoma in a metastasized stage.

AIM

A summarized overview of the current state of knowledge and a summary of the results of currently available studies.

MATERIAL AND METHODS

A systematic search was carried out in MEDLINE and PubMed with respect to metastasized pancreatic cancer and surgical resection.

RESULTS

The evidence level for surgical resection in the metastasized stage is weak and so far no prospective trials are available. The largest single-arm trial included 85 patients with hepatic metastasis. In cases of hepatic oligometastasis an overall survival of 11-14 months was observed. In the presence of pulmonary metastasis, overall survival seems to be prolonged compared to intra-abdominal metastasis, although the evidence level is relatively weak.

CONCLUSION

According to the available results, a general recommendation for surgical resection in a metastasized stage cannot be given; however, the results show a possible benefit for some well-selected patient subgroups. Prospective trials must validate these data and investigate the use of combined surgical and systemic treatments in the case of resectable metastatic pancreatic cancer.