Marrufo B, Menendez-Pelaez A, Buzzell G R, Gonzalez-Brito A, Reiter R J
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
Proc Soc Exp Biol Med. 1989 Nov;192(2):192-5. doi: 10.3181/00379727-192-42978.
The effects of ovariectomy and exogenous androgen administration on the indole and porphyrin metabolism of Syrian hamster Harderian glands were studied. Ovariectomy alone had no effect on any of the parameters analyzed. The administration of either testosterone or 5 alpha-dihydrotestosterone increased the activity of N-acetyltransferase in the Harderian glands. However, androgen treatment failed to change the activity of hydroxyindole-O-methyltransferase. Melatonin content of the glands dropped 20 days after treatment with testosterone and 10 days after the administration of 5 alpha-dihydrotestosterone. The porphyrin content of the Harderian glands was dramatically depressed after the administration of either androgen. It is concluded that the Harderian glands of Syrian hamsters are under an androgenic control involving 5 alpha-dihydrotestosterone.
研究了卵巢切除和外源性雄激素给药对叙利亚仓鼠哈德氏腺吲哚和卟啉代谢的影响。单独卵巢切除对所分析的任何参数均无影响。睾酮或5α-二氢睾酮给药均增加了哈德氏腺中N-乙酰转移酶的活性。然而，雄激素治疗未能改变羟基吲哚-O-甲基转移酶的活性。睾酮治疗20天后以及5α-二氢睾酮给药10天后，腺体中的褪黑素含量下降。给予任何一种雄激素后，哈德氏腺的卟啉含量均显著降低。得出的结论是，叙利亚仓鼠的哈德氏腺受涉及5α-二氢睾酮的雄激素控制。
