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低频全身振动可增强膝骨关节炎小鼠软骨降解，对正常关节无形态学影响，仅轻微改变软骨下骨。

Low-frequency whole-body vibration can enhance cartilage degradation with slight changes in subchondral bone in mice with knee osteoarthritis and does not have any morphologic effect on normal joints.

机构信息

Rehabilitation Medicine Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Center of Rehabilitation Engineering Technology Research, Henan Province, Zhengzhou, Henan, China.

出版信息

PLoS One. 2023 Aug 17;18(8):e0270074. doi: 10.1371/journal.pone.0270074. eCollection 2023.

DOI:10.1371/journal.pone.0270074
PMID:37590222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10434961/
Abstract

PURPOSES: To evaluate the effects of low frequency whole-body vibration (WBV) on degeneration of articular cartilage and subchondral bone in mice with destabilization of the medial meniscus (DMM)induced osteoarthritis(OA) and mice with normal knee. METHODS: Ten-week-old C57BL/6J male mice received DMM on right knees, while the left knees performed sham operation. There were six groups: DMM, SHAM DMM, DMM+WBV,SHAM DMM+WBV, DMM+ NON-WBV and SHAM DMM+NON-WBV. After four weeks, the knees were harvested from the DMM and SHAM DMM group. The remaining groups were treated with WBV (10 Hz) or NON-WBV. Four weeks later, the knees were harvested. Genes, containing Aggrecan(Acan) and CollagenⅡ(Col2a1), Matrix Metalloproteinases 3 and 13(MMP3,13), TNFα and IL6, were measured and staining was also performed. OA was graded with OARSI scores, and tibial plateaubone volume to tissue volume ratio(BV/TV), bone surface area to bone volume ratio (BS/BV), trabecular number(Tb.N) and trabecular thickness separation(TS) between groups were analyzed. RESULTS: Increased OARSI scores and cartilage degradation were observed after WBV. BV/TV, Tb.N and TS were not significant between the groups. Significant reductions were observed in MMP3, MMP13, Col2a1, Acan, TNFα and IL6 in the DMM+WBV compared to SHAM DMM+WBV group. BV/TV, BS/BV, Tb.N, TS and OARSI scores were not significantly changed in the left knees. IL6 expression in the SHAM DMM+WBV group was significantly increased compared with the SHAM DMM+ NON-WBV group, while Col2a1, Acan and MMP13 expression decreased. CONCLUSION: WBV accelerated cartilage degeneration and caused slight changes in subchondral bone in a DMM-induced OA model. WBV had no morphologic effect on normal joints.

摘要

目的：评估低频全身振动（WBV）对内侧半月板不稳定（DMM）诱导的骨关节炎（OA）和正常膝关节小鼠关节软骨和软骨下骨退变的影响。

方法：10 周龄 C57BL/6J 雄性小鼠右膝关节接受 DMM，左膝关节行假手术。共分为 6 组：DMM、SHAM DMM、DMM+WBV、SHAM DMM+WBV、DMM+NON-WBV 和 SHAM DMM+NON-WBV。4 周后，从 DMM 和 SHAM DMM 组取膝关节。其余各组接受 WBV（10 Hz）或 NON-WBV 治疗。4 周后，取膝关节。测量软骨蛋白聚糖（Acan）和Ⅱ型胶原（Col2a1）、基质金属蛋白酶 3 和 13（MMP3、13）、TNFα 和 IL6 等基因的表达，并进行染色。采用 OARSI 评分对 OA 进行分级，并分析各组胫骨平台骨体积与组织体积比（BV/TV）、骨表面积与骨体积比（BS/BV）、骨小梁数（Tb.N）和骨小梁厚度分离（TS）。

结果：WBV 后 OARSI 评分增加，软骨降解。各组间 BV/TV、Tb.N 和 TS 无显著差异。与 SHAM DMM+WBV 组相比，DMM+WBV 组 MMP3、MMP13、Col2a1、Acan、TNFα 和 IL6 表达显著降低。左膝关节 BV/TV、BS/BV、Tb.N、TS 和 OARSI 评分无明显变化。SHAM DMM+WBV 组 IL6 表达明显高于 SHAM DMM+NON-WBV 组，而 Col2a1、Acan 和 MMP13 表达降低。

结论：WBV 加速软骨退变，对 DMM 诱导的 OA 模型软骨下骨造成轻微改变。WBV 对正常关节无形态学影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca12/10434961/802cc8f856a5/pone.0270074.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca12/10434961/1f4691963cf5/pone.0270074.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca12/10434961/9242415a6ccd/pone.0270074.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca12/10434961/c6dae0869fd3/pone.0270074.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca12/10434961/f53315ebd863/pone.0270074.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca12/10434961/802cc8f856a5/pone.0270074.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca12/10434961/1f4691963cf5/pone.0270074.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca12/10434961/9242415a6ccd/pone.0270074.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca12/10434961/c6dae0869fd3/pone.0270074.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca12/10434961/f53315ebd863/pone.0270074.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca12/10434961/802cc8f856a5/pone.0270074.g005.jpg

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引用本文的文献

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本文引用的文献

[1]
AAOS Clinical Practice Guideline Summary: Management of Osteoarthritis of the Knee (Nonarthroplasty), Third Edition.

J Am Acad Orthop Surg. 2022-5-1

[2]
Effects of Whole-Body Vibration Therapy on Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Rehabil Med. 2022-3-29

[3]
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J Exerc Sci Fit. 2021-7

[4]
Pulsed Electromagnetic Field Versus Whole Body Vibration on Cartilage and Subchondral Trabecular Bone in Mice With Knee Osteoarthritis.

Bioelectromagnetics. 2020-5

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BMJ Open. 2020-1-20

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[10]
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J Aging Phys Act. 2020-4-24

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