膝骨关节炎患者上下楼梯行走的生物力学特征:一项系统评价与荟萃分析,旨在更好地定义临床特征。
Biomechanical characteristics of stair ambulation in patients with knee OA: A systematic review with meta-analysis toward a better definition of clinical hallmarks.
作者信息
Iijima Hirotaka, Shimoura Kanako, Aoyama Tomoki, Takahashi Masaki
机构信息
Department of System Design Engineering, Keio University, Yokohama, Japan; Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Japan Society for the Promotion of Science, Tokyo, Japan.
Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
出版信息
Gait Posture. 2018 May;62:191-201. doi: 10.1016/j.gaitpost.2018.03.002. Epub 2018 Mar 8.
BACKGROUND
Stair climbing was suggested to be the first affected task in individuals with knee osteoarthritis (OA).
RESEARCH QUESTION
This review aimed to identify consistent kinematic, kinetic, and spatiotemporal alterations of stair climbing exhibited by individuals with knee OA.
METHODS
A literature search published until September 2017 was conducted in PubMed, PEDro, CINAHL, and Cochrane CENTRAL. Reviewer extracted data in accordance with the Cochrane Handbook. Where possible, data were combined into a meta-analysis; the pooled standardized mean differences between individuals with knee OA and healthy adults were calculated using the random-effect model.
RESULTS
In total, 585 potentially relevant articles were selected, of which 12 (695 participants, mean age: 58.4 years) met the inclusion criteria. Meta-analysis revealed that kinematic and kinetic alterations during stair climbing associated with knee OA were lower external knee flexion moment in conjunction with a larger trunk/hip flexion angles and smaller knee flexion/ankle dorsiflexion angles. Individuals with knee OA showed a delayed quadriceps activation during stair ascent. A lack of evidence was detected for alterations in external knee adduction moment during stair climbing. Effect estimate in each meta-analysis was judged "very low" on the GRADE approach.
SIGNIFICANCE
No strong conclusion can be drawn because of the low quality of evidence; however, individuals with knee OA may exhibit altered kinematics and kinetics changes in sagittal plane during stair climbing, and have delayed quadriceps muscle activity. Further studies with adequate adjustment for confounders are warranted to facilitate clinical hallmarks of the knee OA, particularly in early stages of the disease.
背景
爬楼梯被认为是膝骨关节炎(OA)患者首先受到影响的活动。
研究问题
本综述旨在确定膝骨关节炎患者在爬楼梯时一致的运动学、动力学和时空变化。
方法
在PubMed、PEDro、CINAHL和Cochrane CENTRAL中检索截至2017年9月发表的文献。评审员根据Cochrane手册提取数据。在可能的情况下,将数据合并进行荟萃分析;使用随机效应模型计算膝骨关节炎患者与健康成年人之间的合并标准化平均差异。
结果
总共筛选出585篇可能相关的文章,其中12篇(695名参与者,平均年龄:58.4岁)符合纳入标准。荟萃分析显示,与膝骨关节炎相关的爬楼梯过程中的运动学和动力学变化包括:膝关节外侧屈曲力矩降低,同时躯干/髋关节屈曲角度增大,膝关节屈曲/踝关节背屈角度减小。膝骨关节炎患者在爬楼梯上升过程中股四头肌激活延迟。未发现爬楼梯过程中膝关节内收力矩改变的证据。根据GRADE方法,每项荟萃分析的效应估计被判定为“非常低”。
意义
由于证据质量低,无法得出强有力的结论;然而,膝骨关节炎患者在爬楼梯时矢状面的运动学和动力学可能会发生改变,股四头肌活动延迟。有必要进行进一步的研究,对混杂因素进行充分调整,以促进膝骨关节炎的临床特征,特别是在疾病的早期阶段。