液体活检在癌症早期检测和监测中的应用进展。
Advances in liquid biopsy approaches for early detection and monitoring of cancer.
机构信息
Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
出版信息
Genome Med. 2018 Mar 20;10(1):21. doi: 10.1186/s13073-018-0533-6.
Abstract
Progress in sensitive analytical approaches has opened new avenues for the detection of cells or products such as circulating cell-free DNA released by tumors. These 'liquid biopsies' are being explored in clinical trials for early cancer detection, prediction of recurrent disease, and assessment of therapeutic resistance mechanisms.
摘要
敏感分析方法的进展为检测肿瘤释放的循环无细胞 DNA 等细胞或产物开辟了新途径。这些“液体活检”正在临床试验中用于早期癌症检测、复发疾病预测和治疗耐药机制评估。
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本文引用的文献
1
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Science. 2018 Feb 23;359(6378):926-930. doi: 10.1126/science.aar3247. Epub 2018 Jan 18.
2
Cell-Free DNA in Oncology: Gearing up for Clinic.肿瘤游离 DNA：为临床应用做好准备。
Ann Lab Med. 2018 Jan;38(1):1-8. doi: 10.3343/alm.2018.38.1.1.
3
Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence.1q21.3 染色体扩增是乳腺癌复发的一种可追踪的生物标志物和可操作的靶点。
Nat Med. 2017 Nov;23(11):1319-1330. doi: 10.1038/nm.4405. Epub 2017 Sep 25.
4
Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling.局部肺癌中循环肿瘤 DNA 谱分析的分子残留疾病的早期检测。
Cancer Discov. 2017 Dec;7(12):1394-1403. doi: 10.1158/2159-8290.CD-17-0716. Epub 2017 Sep 24.
5
Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition.循环游离 DNA 指导 PARP 抑制治疗前列腺癌。
Cancer Discov. 2017 Sep;7(9):1006-1017. doi: 10.1158/2159-8290.CD-17-0261. Epub 2017 Apr 27.
6
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