Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Int J Biol Sci. 2023 Jan 1;19(1):167-182. doi: 10.7150/ijbs.78321. eCollection 2023.
Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exosomes can modulate drug resistance via multiple mechanisms. This review attempts to elucidate the mechanisms of exosomal cargoes with reference to tumor drug resistance, their role in genitourinary cancers, and their potential clinical applications as candidate biomarkers in liquid biopsy.
耐药性是泌尿生殖系统癌症治疗的主要障碍。外泌体作为细胞间通讯的介质，具有重要的生物学功能，并在包括药物反应在内的病理过程中发挥重要作用。通过传递生物活性货物，外泌体可以通过多种机制调节耐药性。本综述试图阐明与肿瘤耐药性相关的外泌体货物的机制、它们在泌尿生殖系统癌症中的作用，以及它们作为液体活检候选生物标志物的潜在临床应用。
