Faculty of Applied Sciences, UCSI University, Cheras, Kuala Lumpur 56000, Malaysia.
School of Science, Monash University, Petaling Jaya, Selangor 46150, Malaysia.
J Integr Med. 2018 May;16(3):147-152. doi: 10.1016/j.joim.2018.03.001. Epub 2018 Mar 6.
This short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond, two hydroxyl groups and four methoxyl groups. Casticin has been isolated from various tissues of plants in the Vitex genus: fruits and leaves of V. trifolia, aerial parts and seeds of V. agnus-castus and leaves of V. negundo. Studies have reported the antiproliferative and apoptotic activities of casticin from Vitex species. The compound is effective against many cancer cell lines via different molecular mechanisms. Studies have also affirmed the anti-inflammatory properties of casticin, with several molecular mechanisms identified. Other pharmacological properties include anti-asthmatic, tracheospasmolytic, analgesic, antihyperprolactinemia, immunomodulatory, opioidergic, oestrogenic, anti-angiogenic, antiglioma, lung injury protection, rheumatoid arthritis amelioration and liver fibrosis attenuation activities. Clinical trials and commercial use of the casticin-rich fruit extract of V. agnus-castus among women with premenstrual syndrome were briefly discussed.
这篇简短的综述更新了牡荆素（Vitex 属植物中的一种）的抗癌和抗炎特性。牡荆素是一种具有三环、邻苯二酚部分、双键、两个羟基和四个甲氧基的多甲氧基黄酮。牡荆素已从牡荆属植物的各种组织中分离出来：三叶牡荆的果实和叶子、牡荆的地上部分和种子以及黄荆的叶子。研究报告称，牡荆素具有抗增殖和促凋亡活性。该化合物通过不同的分子机制对多种癌细胞系有效。研究还证实了牡荆素的抗炎特性，确定了几种分子机制。其他药理特性包括抗哮喘、气管痉挛缓解、镇痛、抗高泌乳素血症、免疫调节、阿片样、雌激素、抗血管生成、抗神经胶质瘤、肺损伤保护、类风湿性关节炎改善和肝纤维化减轻活性。简要讨论了牡荆素（牡荆属）富果提取物在经前期综合征妇女中的临床试验和商业用途。
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