当前母婴免疫研究的挑战与成就。
Current Challenges and Achievements in Maternal Immunization Research.
机构信息
Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
出版信息
Front Immunol. 2018 Mar 6;9:436. doi: 10.3389/fimmu.2018.00436. eCollection 2018.
Abstract
Maternal immunization has the potential to significantly improve maternal and child health worldwide by reducing maternal and infant morbidity and mortality associated with disease caused by pathogens that are particularly relevant in the perinatal period and in early life, and for which no alternative effective preventive strategies exist. Research on all aspects related to vaccines for administration during pregnancy is ongoing with support of multiple stakeholders and global participation. Substantial progress has been made, and the availability of new vaccines licensed exclusively for use in pregnant women to protect their infants has become an achievable goal. This review provides an update of the current challenges and achievements in maternal immunization research, focusing on recent milestones that advance the field and the prospects to make maternal immunization a feasible and accessible strategy to improve global health.
摘要
母亲免疫接种有可能通过降低与围产期和生命早期特别相关的病原体引起的母婴发病率和死亡率，改善全球母婴健康，这些病原体目前尚无其他有效的预防策略。在多方利益相关者的支持和全球参与下，正在对与妊娠期间接种疫苗相关的各个方面进行研究。已经取得了实质性进展，并且获得了专门为保护其婴儿而在孕妇中使用的新疫苗，这一目标即将实现。本综述提供了母亲免疫接种研究中当前挑战和成就的最新信息，重点介绍了推进该领域的最新里程碑以及使母亲免疫接种成为改善全球健康的可行和可及策略的前景。
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