橄榄狒狒基因组中谱系特异性亚家族的分析
Analysis of lineage-specific subfamilies in the genome of the olive baboon, .
作者信息
Steely Cody J, Baker Jasmine N, Walker Jerilyn A, Loupe Charles D, Batzer Mark A
机构信息
Department of Biological Sciences, Louisiana State University, 202 Life Sciences Bldg., Baton Rouge, LA 70803 USA.
出版信息
Mob DNA. 2018 Mar 19;9:10. doi: 10.1186/s13100-018-0115-6. eCollection 2018.
BACKGROUND
elements are primate-specific retroposons that mobilize using the enzymatic machinery of L1 s. The recently completed baboon genome project found that the mobilization rate of elements is higher than in the genome of any other primate studied thus far. However, the subfamily structure present in and specific to baboons had not been examined yet.
RESULTS
Here we report 129 subfamilies that are propagating in the genome of the olive baboon, with 127 of these subfamilies being new and specific to the baboon lineage. We analyzed 233 insertions in the genome of the olive baboon using locus specific polymerase chain reaction assays, covering 113 of the 129 subfamilies. The allele frequency data from these insertions show that none of the nine groups of subfamilies are nearing fixation in the lineage.
CONCLUSIONS
Many subfamilies of elements are actively mobilizing throughout the baboon lineage, with most being specific to the baboon lineage.
背景
元件是灵长类特有的逆转座子，利用L1的酶促机制进行移动。最近完成的狒狒基因组计划发现，元件的移动速率高于迄今为止所研究的任何其他灵长类动物的基因组。然而，狒狒特有的亚家族结构尚未得到研究。
结果
在此我们报告了129个在东非狒狒基因组中正在传播的亚家族，其中127个亚家族是狒狒谱系特有的新亚家族。我们使用位点特异性聚合酶链反应分析，分析了东非狒狒基因组中的233个插入序列，涵盖了129个亚家族中的113个。这些插入序列的等位基因频率数据表明，九组亚家族中没有一组在谱系中接近固定状态。
结论
元件的许多亚家族在整个狒狒谱系中都在积极移动，大多数亚家族是狒狒谱系特有的。
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