Jang Bian, Moorthy Madhappan Santha, Manivasagan Panchanathan, Xu Li, Song Kyeongeun, Lee Kang Dae, Kwak Minseok, Oh Junghwan, Jin Jun-O
Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Jinshan District, Shanghai, China.
Marine-Integrated Bionics Research Center, Pukyong National University, Busan, South Korea.
Oncotarget. 2018 Jan 3;9(16):12649-12661. doi: 10.18632/oncotarget.23898. eCollection 2018 Feb 27.
In advanced cancer therapy, the combinational therapeutic effect of photothermal therapy (PTT) using near-infrared (NIR) light-responsive nanoparticles (NPs) and anti-cancer drug delivery-mediated chemotherapy has been widely applied. In the present study, using a facile, low-cost, and solution-based method, we developed and synthesized fucoidan, a natural polymer isolated from seaweed that has demonstrated anti-cancer effect, and coated NPs with it as an ideal candidate in chemo-photothermal therapy against cancer cells. Fucoidan-coated copper sulfide nanoparticles (F-CuS) act not only as a nanocarrier to enhance the intracellular delivery of fucoidan but also as a photothermal agent to effectively ablate different cancer cells (e.g., HeLa, A549, and K562), both and , with the induction of apoptosis under 808 nm diode laser irradiation. These results point to the potential usage of F-CuS in treating human cancer.
在晚期癌症治疗中，使用近红外（NIR）光响应纳米颗粒（NPs）的光热疗法（PTT）与抗癌药物递送介导的化疗的联合治疗效果已得到广泛应用。在本研究中，我们采用一种简便、低成本且基于溶液的方法，开发并合成了从海藻中分离出的具有抗癌作用的天然聚合物岩藻聚糖，并用其包覆纳米颗粒，作为癌症细胞化学光热疗法的理想候选物。岩藻聚糖包覆的硫化铜纳米颗粒（F-CuS）不仅作为纳米载体增强岩藻聚糖的细胞内递送，还作为光热剂有效地消融不同的癌细胞（如HeLa、A549和K562），在808 nm二极管激光照射下诱导凋亡，无论是体外还是体内。这些结果表明F-CuS在治疗人类癌症方面具有潜在用途。
