Agardh E, Tallroth G, Bauer B, Cavallin-Sjöberg U, Agardh C D
Diabet Med. 1987 May-Jun;4(3):248-50. doi: 10.1111/j.1464-5491.1987.tb00873.x.
The association between retinopathy and nephropathy was investigated in a retrospective study of 52 insulin-dependent diabetics with preproliferative or proliferative retinopathy and in 48 patients without or with background retinopathy. The duration of diabetes was 23.2 +/- 1.0 years (mean +/- SEM) and 22.0 +/- 1.2 years in the two groups. Patients in the retinopathy group showed a higher frequency of detectable nephropathy and were more often treated with antihypertensive drugs. However, a high proportion (35%) of patients with proliferative retinopathy did not show any detectable signs of nephropathy. Furthermore, nephropathy did not seem to develop in patients with retinopathy during an observation period of up to 9 years. The data suggest that the factors underlying the development of retinal and renal microangiopathy might be of different origin.
在一项回顾性研究中，对52例患有增殖前期或增殖性视网膜病变的胰岛素依赖型糖尿病患者以及48例无视网膜病变或仅有背景性视网膜病变的患者进行了视网膜病变与肾病之间关联的调查。两组患者的糖尿病病程分别为23.2±1.0年（均值±标准误）和22.0±1.2年。视网膜病变组患者可检测到的肾病发生率更高，且更常接受抗高血压药物治疗。然而，高比例（35%）的增殖性视网膜病变患者未表现出任何可检测到的肾病迹象。此外，在长达9年的观察期内，视网膜病变患者似乎并未发生肾病。数据表明，视网膜和肾脏微血管病变发生的潜在因素可能源于不同方面。
