香鳞毛蕨（Dryopteris fragrans (L.) Schott.）中的抗癌类黄酮

Anticancer Phenolics from Dryopteris fragrans (L.) Schott.

机构信息

Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Ministry of Education/Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Harbin 150040, China.

Sino-Russian Joint Laboratory of Bioactive Substance, College of Life Science, Heilongjiang University, Harbin 150080, China.

出版信息

Molecules. 2018 Mar 17;23(3):680. doi: 10.3390/molecules23030680.

DOI:10.3390/molecules23030680

PMID:29562617

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6017300/

Abstract

Cancer is one of the most major diseases that threatens human health and life. The aim of this work was to obtain novel anticancer molecules from , a kind of medicinal plant. The structure of the new compound was identified using spectroscopic data (¹H-NMR, C-NMR and two dimensions NMR). Its anticancer properties were evaluated using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2--tetrazolium bromide (MTT) assay against four human cells including lung cancer cells (A549), breast cancer cells (MCF-7), gastric cancer cells (SGC7901) and noncancerous human umbilical vein endothelial cells (HUVEC). A new phenylpropanoid-()-caffeic acid-9--β-d-xylpyranosyl-(1→2)-β-d-glucopyranosyl ester (), with seven known compounds (-)-was isolated. The IC value of compound against MCF-7 cells was 2.65 ± 0.14 µM, and the IC values of compound against three cancer cells were below 20 µM.

摘要

癌症是威胁人类健康和生命的最主要疾病之一。本工作旨在从药用植物中获得新型抗癌分子。利用光谱数据（1H-NMR、C-NMR 和二维 NMR）确定新化合物的结构。利用 3-（4,5-二甲基-2-噻唑基）-2,5-二苯基-2-H-四唑溴盐（MTT）测定法，对四种人类细胞（肺癌细胞 A549、乳腺癌细胞 MCF-7、胃癌细胞 SGC7901 和非癌细胞人脐静脉内皮细胞 HUVEC）进行了评估，评估了新化合物的抗癌特性。从药用植物中分离得到一种新的苯丙素类化合物（）-咖啡酸-9-O-β-D-吡喃木糖基-（1→2）-β-D-吡喃葡萄糖苷（），并鉴定了 7 种已知化合物（-）-。化合物对 MCF-7 细胞的 IC 值为 2.65±0.14µM，化合物对三种癌细胞的 IC 值均低于 20µM。