鉴定新型倍半萜及香鳞毛蕨化学成分的抗真菌活性
Characterization of a new sesquiterpene and antifungal activities of chemical constituents from Dryopteris fragrans (L.) Schott.
机构信息
Key Laboratory of Molecular Biology of Heilongjiang Province, College of Life Science, Heilongiang University, Harbin 150080, China.
Pharmaceutical College, Harbin Medical University, Harbin 150086, China.
出版信息
Molecules. 2014 Jan 2;19(1):507-13. doi: 10.3390/molecules19010507.
One new sesquiterpene and six known compounds were isolated from Dryopteris fragrans (L.) Schot. They were identified as 3-O-β-D-glucopyranosylalbicanol- 11-O-β-D-glucopyranoside (1), dihydroconiferylalcohol (2), (E)-3-(4-hydroxyphenyl)acrylic acid (3), esculetin (4), 5,7-dihydroxy-2-hydroxymethylchromone (5), eriodictyol (6) and isoorientin (7) by UV, MS, 1D-NMR and 2D-NMR spectroscopy. The antifungal activities of the seven isolated compounds were screened. Compounds 2, 3, 4 and 5 showed obvious activities against Microsporum canis and Epidermophyton floccosum.
从香鳞毛蕨中分离得到一个新的倍半萜和六个已知化合物。它们被鉴定为 3-O-β-D-吡喃葡萄糖基阿尔比坎醇-11-O-β-D-吡喃葡萄糖苷（1）、二氢松柏醇（2）、（E）-3-（4-羟基苯基）丙烯酸（3）、秦皮素（4）、5,7-二羟基-2-羟甲基色酮（5）、圣草酚（6）和异荭草苷（7），通过 UV、MS、1D-NMR 和 2D-NMR 光谱鉴定。对七种分离化合物进行了抗真菌活性筛选。化合物 2、3、4 和 5 对犬小孢子菌和絮状表皮癣菌表现出明显的活性。
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