一种新型人癌细胞增殖抑制倍半萜，来自药用植物旱蕨（L.）的 Dryofraterpene A。
A New Human Cancer Cell Proliferation Inhibition Sesquiterpene, Dryofraterpene A, from Medicinal Plant Dryopteris fragrans (L.) Schott.
机构信息
Food Science Department of XiZang Agriculture and Animal Husbandry College, Xizang 860000, China.
Key Laboratory of Molecular Biology of Heilongjiang Province, College of Life Science, Heilongjiang University, Harbin 150080, China.
出版信息
Molecules. 2017 Jan 21;22(1):180. doi: 10.3390/molecules22010180.
The global burden of cancer continues to increase largely with the aging and growth of the world population. The purpose of the present work was to find new anticancer molecules from a natural source. We utilized chromatographic methods to isolate compounds from medicinal plant (L.) Schott. The structure of the new compounds was determined by spectroscopic and spectrometric data (1D NMR, 2D NMR, and EMI-MS). Their anti-proliferation effects against five human cancer cell lines including A549, MCF7, HepG2, HeLa, and PC-3 were evaluated by CCK-8 andlactate dehydrogenase (LDH) assay. A new sesquiterpene, (7, 10)-2,3-dihydroxy-calamenene-15-carboxylic acid methyl ester (), and two known compounds ( and ) were isolated. The new sesquiterpene was named dryofraterpene A and significantly inhibited cancer cell proliferation without any obvious necrosis below a 10 μM concentration. In conclusion, a novel anticancer sesquiterpene together with two known compounds was isolated, which might be a promising lead compound for the treatment of cancer.
全球癌症负担继续大幅增加，主要是由于世界人口的老龄化和增长。本工作的目的是从天然来源中寻找新的抗癌分子。我们利用色谱方法从药用植物（L.）Schott 中分离化合物。新化合物的结构通过光谱和光谱数据（1D NMR、2D NMR 和 EMI-MS）确定。通过 CCK-8 和乳酸脱氢酶（LDH）测定评估了它们对五种人癌细胞系（A549、MCF7、HepG2、HeLa 和 PC-3）的抗增殖作用。分离得到一种新的倍半萜烯、（7,10）-2,3-二羟基-千金子烯-15-羧酸甲酯（）和两种已知化合物（和）。新的倍半萜烯被命名为干呋拉醇 A，在低于 10 μM 的浓度下，没有明显的坏死，显著抑制癌细胞增殖。总之，从天然来源中分离到一种新型的抗癌倍半萜烯化合物以及两种已知化合物，它们可能是治疗癌症的有前途的先导化合物。
Zotero 插件