Rubinow D R, Peck G L, Squillace K M, Gantt G G
J Am Acad Dermatol. 1987 Jul;17(1):25-32. doi: 10.1016/s0190-9622(87)70166-2.
We evaluated the psychiatric morbidity and mood characteristics of a group (n = 72) of patients with cystic acne before and after treatment with one of three dosage schedules of isotretinoin. Although no excess psychiatric morbidity was observed, substantial evidence of psychologic distress was noted before treatment. Significant reductions in anxiety were observed on several measures of anxiety after treatment, with mitigation of anxiety and depression most robust in those patients with the greatest dermatologic improvement with isotretinoin.
我们评估了一组（n = 72）囊性痤疮患者在接受三种异维A酸剂量方案之一治疗前后的精神疾病发病率和情绪特征。虽然未观察到精神疾病发病率过高，但在治疗前发现了明显的心理困扰迹象。治疗后，多项焦虑测量指标显示焦虑显著降低，对于那些使用异维A酸治疗后皮肤改善最明显的患者，焦虑和抑郁的缓解最为显著。
