J Drugs Dermatol. 2021 Feb 1;20(2):172-177. doi: 10.36849/JDD.5559.
Little is known regarding differential effects of systemic anti-acne treatments on mental health.
To determine whether differences exist in mental health outcomes between acne patients treated with isotretinoin versus oral antibiotics (doxycycline, minocycline, or tetracycline).
Population study utilizing the 2004-2017 Medical Expenditure Panel Survey. Depressive symptoms were assessed using Patient Health Questionnaire 2 (PHQ-2); psychological distress was measured by the Kessler 6-Item Psychological Distress Scale (K6). Acne patients completed both the PHQ-2 and K6 during treatment with isotretinoin or oral antibiotics. Lower scores on both measures indicate better mental health outcomes.
After adjusting for socio-demographic characteristics, patients on isotretinoin had fewer depressive symptoms than patients on oral antibiotics, as measured by mean PHQ-2 scores (isotretinoin 0.280 vs oral antibiotics 0.656, difference=0.337, P<0.01). The adjusted comparison also showed patients on isotretinoin had less psychological distress than patients on oral antibiotics, as measured by K6 scores (isotretinoin 2.494 vs oral antibiotics 3.433, difference=0.759, P=0.043).
No direct assessment of acne severity.
Acne patients on isotretinoin experienced less depressive symptoms and psychological distress as compared to oral antibiotics. J Drugs Dermatol. 2021;20(2):172-177. doi:10.36849/JDD.5559.
关于系统性抗痤疮治疗对心理健康的影响，人们知之甚少。
确定痤疮患者接受异维 A 酸与口服抗生素（多西环素、米诺环素或四环素）治疗时，心理健康结果是否存在差异。
利用 2004-2017 年医疗支出调查进行人群研究。使用患者健康问卷 2（PHQ-2）评估抑郁症状；使用 Kessler 6 项心理困扰量表（K6）测量心理困扰。痤疮患者在接受异维 A 酸或口服抗生素治疗期间完成 PHQ-2 和 K6。两个指标的得分越低，表明心理健康结果越好。
在调整了社会人口统计学特征后，与口服抗生素相比，接受异维 A 酸治疗的患者抑郁症状更少，这一点通过 PHQ-2 平均得分来衡量（异维 A 酸为 0.280，口服抗生素为 0.656，差值=0.337，P＜0.01）。调整后的比较还显示，与口服抗生素相比，接受异维 A 酸治疗的患者心理困扰更少，这一点通过 K6 得分来衡量（异维 A 酸为 2.494，口服抗生素为 3.433，差值=0.759，P=0.043）。
未直接评估痤疮严重程度。
与口服抗生素相比，接受异维 A 酸治疗的痤疮患者抑郁症状和心理困扰更少。《皮肤病药物杂志》。2021;20(2):172-177。doi:10.36849/JDD.5559.
