6 岁时致敏与非哮喘患者随后的气道高反应性有关。
sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics.
机构信息
Pediatric Pulmonary Allergy Division, Department of Pediatrics, University of Arizona, Tucson, Arizona, USA.
Asthma and Airway Disease Research Center, University of Arizona, Tucson, Arizona, USA.
出版信息
Thorax. 2018 Dec;73(12):1170-1173. doi: 10.1136/thoraxjnl-2017-210325. Epub 2018 Mar 21.
Abstract
In the non-selected birth cohort Tucson Children's Respiratory Study, early sensitisation to was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than and AHR among non-asthmatics. Why this group of sensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.
摘要
在未选择的出生队列图森儿童呼吸研究中，非哮喘患者早期对 过敏与成年后气道高反应性（AHR）增加有关。AHR 的增加幅度与 致敏哮喘患者相似，主要见于超重或肥胖者。相比之下，在非哮喘患者中，除 以外的其他气传过敏原的早期致敏与 AHR 之间没有显著关联。为什么这群没有哮喘的 致敏个体表现出与哮喘患者相似程度的 AHR 尚不清楚，需要进一步研究。
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