Laboratory Medicine, Shuyang People's Hospital, Shuyang, Jiangsu, China (mainland).
Laboratory Medicine, Shuyang Affiliated Hospital of Xuzhou Medical University, Shuyang, Jiangsu, China (mainland).
Med Sci Monit. 2018 Mar 22;24:1688-1692. doi: 10.12659/msm.909226.
BACKGROUND We aimed to predict the abnormal LDL level by using TG, TC, HDL, and non-HDL in this study. MATERIAL AND METHODS Triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) data were obtained from the Laboratory Information System (LIS) for 4 years (Oct 1, 2013 to Sept 30, 2017) from among 34 270 healthy Chinese patients at Shuyang People's Hospital. TG, TC, HDL, and LDL (direct clearance method) were measured using a TBA2000FR biochemical analyzer. The non-HDL was calculated as TC minus HDL. Correlations between TG, TC, non-HDL, and LDL were analyzed using Spearman's rank correlation. Receiver operating characteristics (ROC) curve analysis was used to evaluate the predictive utility of TG, TC, and non-HDL for the abnormal LDL level (<130 mg/dL). RESULTS Both TC (r=0.870) and non-HDL (r=0.893) were significantly positively correlated with LDL. The area under curve of TC and non-HDL can be used to predict abnormal LDL levels. Optimal thresholds were 182.5 mg/Dl (4.72 mmol/L) for TC and 135.3 mg/Dl (3.50 mmol/L) for non-HDL. Based on these optimal thresholds, less than 0.5% and 0.4% of tests with elevated LDL were missed using TC and non-HDL, respectively, but the value of these missed LDL levels was not very high (<147.3 mg/dL). CONCLUSIONS If the value of non-HDL is less than 135.3 mg/Dl (3.50 mmol/L) and/or TC is less than 182.5 mg/Dl (4.72 mmol/L) for the apparently healthy populations, the LDL level will be less than 130 mg/Dl (3.36 mmol/L). TC and non-HDL can be used to predict the abnormal LDL level in apparently healthy populations.
本研究旨在通过 TG、TC、HDL 和非-HDL 预测 LDL 水平异常。
从沭阳县人民医院 34270 名健康中国患者的实验室信息系统（LIS）中获取 4 年（2013 年 10 月 1 日至 2017 年 9 月 30 日）的 TG、TC、HDL 和 LDL 数据。使用 TBA2000FR 生化分析仪测量 TG、TC、HDL 和 LDL（直接清除法）。非-HDL 计算为 TC 减去 HDL。采用 Spearman 秩相关分析 TG、TC、非-HDL 和 LDL 之间的相关性。采用受试者工作特征（ROC）曲线分析评估 TG、TC 和非-HDL 对 LDL 异常（<130mg/dL）的预测效用。
TC（r=0.870）和非-HDL（r=0.893）与 LDL 均呈显著正相关。TC 和非-HDL 的曲线下面积可用于预测 LDL 水平异常。TC 的最佳截断值为 182.5mg/dL（4.72mmol/L），非-HDL 的最佳截断值为 135.3mg/dL（3.50mmol/L）。基于这些最佳截断值，TC 和非-HDL 分别漏诊<147.3mg/dL 的 LDL 异常<0.5%和<0.4%，但漏诊 LDL 水平值不高（<147.3mg/dL）。
如果非-HDL 水平<135.3mg/dL（3.50mmol/L）和/或 TC 水平<182.5mg/dL（4.72mmol/L），则明显健康人群的 LDL 水平将<130mg/dL（3.36mmol/L）。TC 和非-HDL 可用于预测明显健康人群的 LDL 水平异常。
