Departamento de Física, Universidad de Oviedo, Oviedo, E-33007, Spain.
Oncology University Institute of the Principality of Asturias (IUOPA), Oviedo, 33006, Spain.
Sci Rep. 2018 Mar 21;8(1):4964. doi: 10.1038/s41598-018-23321-6.
The precise determination of dose-effect curves and the combination effect of drugs is of crucial importance in the development of new therapies for the most dreadful diseases. We have found that the current implementations of the theory of Chou et al. are not accurate enough in some circumstances and might lead to erroneous predictions of synergistic or antagonistic behaviour. We have identified the source of inaccuracies and fixed it thereby improving the accuracy of those methods. Here we explain the main features of our approach and demonstrate its higher accuracy as compared to the standard methods. Therefore, this new implementation might have a huge impact in the reliability of future research on new Combination Therapies.
精确确定剂量-效应曲线和药物的组合效应对于开发最可怕疾病的新疗法至关重要。我们发现，Chou 等人的理论目前的实现方式在某些情况下不够准确，可能导致对协同或拮抗行为的错误预测。我们已经确定了不准确的来源，并对其进行了修复，从而提高了这些方法的准确性。在这里，我们解释了我们方法的主要特点，并证明了它与标准方法相比具有更高的准确性。因此，这种新的实现方式可能会对未来新组合疗法研究的可靠性产生巨大影响。
