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饮食模式与癌症发病率和生存率的关联:概念、现有证据及对未来研究的建议。

Dietary patterns in association to cancer incidence and survival: concept, current evidence, and suggestions for future research.

机构信息

Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

出版信息

Eur J Clin Nutr. 2018 Jun;72(6):818-825. doi: 10.1038/s41430-018-0128-8. Epub 2018 Mar 21.

Abstract

Assessing diet through dietary patterns has become popular in diet-disease investigations due to the appealing simplicity of expressing several dietary exposures through one variable. Current evidence suggests that there may exist a priori and a posteriori dietary patterns that are consistently associated with reduced all-cause, as well as site-specific cancer risk across different populations. Typical examples include the Mediterranean dietary pattern, the Healthy Eating Index, a number of "healthy" a posteriori dietary patterns, and others. Despite their apparent differences, by inspecting their components it seems that multiple dietary patterns reflect core constituents of a healthy diet. Ongoing research is targeted to: (a) identify the common features underlying the beneficial-for-cancer-prevention dietary patterns, (b) decompose the estimated associations of dietary patterns with cancer risk to the individual associations of their components, and (c) construct dietary patterns for site-specific cancer risk prediction. Results of these and other initiatives could be helpful for public health policy makers and responsible bodies to (a) better formulate relevant messages for informing people about the components of cancer-preventing diets, and (b) promote small changes in eating patterns that can lower cancer risk and improve cancer outcomes.

摘要

通过饮食模式评估饮食已经在饮食与疾病的研究中变得流行,因为通过一个变量来表达多种饮食暴露具有吸引人的简单性。目前的证据表明,可能存在先验和后验的饮食模式,这些模式与不同人群的全因和特定部位癌症风险降低相关。典型的例子包括地中海饮食模式、健康饮食指数、一些“健康”的后验饮食模式等。尽管它们存在明显差异,但通过检查它们的组成部分,似乎多种饮食模式反映了健康饮食的核心成分。正在进行的研究旨在:(a)确定预防癌症的有益饮食模式的共同特征,(b)将饮食模式与癌症风险的估计关联分解为其组成部分的个体关联,以及(c)构建针对特定部位癌症风险预测的饮食模式。这些和其他举措的结果可能有助于公共卫生政策制定者和责任机构:(a)更好地制定相关信息,告知人们预防癌症饮食的成分;(b)促进可以降低癌症风险和改善癌症结局的饮食模式的微小变化。

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