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1例流感疫苗接种后出现川崎病的婴儿:病例报告

An infant presenting with Kawasaki disease following immunization for influenza: A case report.

作者信息

Jeong Seung Woo, Kim Do Hee, Han Mi Young, Cha Sung-Ho, Yoon Kyung Lim

机构信息

Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul 05278, Republic of Korea.

Department of Pediatrics, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul 02447, Republic of Korea.

出版信息

Biomed Rep. 2018 Mar;8(3):301-303. doi: 10.3892/br.2018.1043. Epub 2018 Jan 16.

Abstract

Kawasaki disease (KD) is a childhood vascular disorder of unknown etiology. Concerns have recently been raised regarding vaccinations as a potential risk factor for KD. In addition, various forms of vasculitis have been reported as adverse events following administration after various vaccines. Patients exhibiting post vaccination KD have previously been described; however, thus far, to the best of our knowledge, only one patient exhibiting post influenza vaccination KD has been reported in Japan. The present study describes a case of KD 24 h after immunization with influenza in an infant (age, 18 months) following 6 days of high fever, a body rash that had persisted for 2 days and nonsuppurative bilateral conjunctivitis. To the best of the authors' knowledge, this is the first reported case in Korea and the present study reviews various recent studies regarding vasculitis following vaccination and the causal association between them.

摘要

川崎病(KD)是一种病因不明的儿童血管疾病。最近,人们对疫苗接种作为KD的潜在危险因素提出了担忧。此外,各种形式的血管炎已被报告为接种各种疫苗后的不良事件。此前已有接种疫苗后出现KD的患者的描述;然而,据我们所知,迄今为止,日本仅报告了1例接种流感疫苗后出现KD的患者。本研究描述了1例18个月大婴儿在接种流感疫苗24小时后发生KD的病例,该婴儿此前已持续高热6天、皮疹持续2天且患有非化脓性双侧结膜炎。据作者所知,这是韩国首例报告病例,本研究回顾了近期关于接种疫苗后血管炎及其因果关联的各种研究。

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Kawasaki disease: A brief history.川崎病:简史
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本文引用的文献

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Vasculitis: determinants of disease patterns.血管炎:疾病模式的决定因素。
Nat Rev Rheumatol. 2014 Aug;10(8):454-62. doi: 10.1038/nrrheum.2014.89. Epub 2014 Jun 17.
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The role of infection in Kawasaki syndrome.感染在川崎病中的作用。
J Infect. 2013 Jul;67(1):1-10. doi: 10.1016/j.jinf.2013.04.004. Epub 2013 Apr 18.
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Infections in vasculitis.血管炎中的感染。
Best Pract Res Clin Rheumatol. 2013 Feb;27(1):19-31. doi: 10.1016/j.berh.2013.01.004.
7
Yellow fever vaccination and Kawasaki disease.黄热病疫苗接种与川崎病
Pediatr Infect Dis J. 2009 Nov;28(11):1037-8. doi: 10.1097/INF.0b013e3181bbc571.
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Kawasaki disease in an infant following immunisation with hepatitis B vaccine.
Clin Rheumatol. 2003 Dec;22(6):461-3. doi: 10.1007/s10067-003-0785-3. Epub 2003 Oct 7.

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