Akintayo Richard Oluyinka, Adelowo Olufemi Oladipo, Egajifo Ochuko, Popoola Rukayyah Abisoye, Odunlami Gbenga Joshua, Emorinken Airenakho, Olaosebikan Babatunde Hakeem
Division of Rheumatology, Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
Division of Rheumatology, Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Nigeria.
Int Ophthalmol. 2019 May;39(5):1003-1012. doi: 10.1007/s10792-018-0902-6. Epub 2018 Mar 21.
Objectives To determine the patterns, predictors and overall impact of ocular manifestations of rheumatoid arthritis (RA) on the health-related quality of life and disability index.
A total of 50 Nigerian patients with RA were studied. Full ocular evaluation was done to determine the presence of each defined ocular manifestation of RA. All patients completed the Medical Outcome Study 36-Item Short Form Health Survey (SF-36) and the Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaires.
The mean ± SD age of the patients was 47.2 ± 12.5 years. A total of 42 cases of ocular diseases were found in 23 (46%) patients. Keratoconjunctivitis sicca was found in 15 (30%) patients; cataract, 13 (26%); scleritis/episcleritis, 4 (8%); disk edema, 4 (8%); glaucoma, 3 (6%); ulcerative keratitis, 1 (2%); vitreitis, 1 (2%); and macula edema, 1 (2%) patient. There is an association of the presence of ocular manifestations with the physical component summary (PCS) [T = - 3.398, P = 0.001] and the mental component summary (MCS) [T = - 2.616, 0.012] of the SF-36 but not with the HAQ-DI (T = 1.685, 0.099). Following multiple regression analysis, the predictors of the presence of ocular manifestations were age greater than 45 years and positive anti-citrullinated protein antibody. Following linear regression analyses, Steinbrocker's functional class independently predicted the PCS while both Steinbrocker's functional class and female sex predicted the MCS.
The development of ocular disorders associated with RA is associated with a significant negative impact on the quality of life of the patients.
目的是确定类风湿关节炎（RA）眼部表现的模式、预测因素及其对健康相关生活质量和残疾指数的总体影响。
共研究了50例尼日利亚RA患者。进行全面的眼部评估以确定每种定义的RA眼部表现的存在情况。所有患者均完成了医学结局研究36项简短健康调查（SF - 36）和健康评估问卷残疾指数（HAQ - DI）问卷。
患者的平均年龄±标准差为47.2±12.5岁。23例（46%）患者共发现42例眼部疾病。15例（30%）患者发现干燥性角结膜炎；13例（26%）为白内障；4例（8%）为巩膜炎/表层巩膜炎；4例（8%）为视盘水肿；3例（6%）为青光眼；1例（2%）为溃疡性角膜炎；1例（2%）为玻璃体炎；1例（2%）为黄斑水肿。眼部表现的存在与SF - 36的身体成分总结（PCS）[T = - 3.398，P = 0.001]和心理成分总结（MCS）[T = - 2.616，0.012]相关，但与HAQ - DI无关（T = 1.685，0.099）。经过多元回归分析，眼部表现存在的预测因素为年龄大于45岁和抗瓜氨酸化蛋白抗体阳性。经过线性回归分析，斯坦布罗克功能分级独立预测PCS，而斯坦布罗克功能分级和女性性别均预测MCS。
与RA相关的眼部疾病的发展对患者的生活质量有显著负面影响。
