Ma Weifang, Wang Guoliang, Li Xiaofeng, Wu Huping, Liu Zuguo, Dong Nuo, Li Cheng
Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, China.
Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, China.
J Ophthalmol. 2020 Aug 8;2020:5768679. doi: 10.1155/2020/5768679. eCollection 2020.
The present study investigated the relationship between dry eye and the disease activity in patients with rheumatoid arthritis (RA).
Patients with RA were divided by the Ocular Surface Disease Index (OSDI) into the symptomatic group (score ≥ 12) and the asymptomatic group (score < 12). By using the Disease Activity Score (DAS-28) questionnaire, they were divided into the active group (score > 2.6) and the stable group (score ≤ 2.6). In the control group, 20 healthy adults with matched sex and age were selected. RA patients and healthy adults were inspected for the tear film break time (TBUT), tear meniscus height (TMH), corneal fluorescein staining (CFS), meibomian scan (MS), meibomian gland secretion score (MSS), and eyelid margin assessment (EMS).
The TBUT of the RA group was significantly less than that of the control group, while the CFS, MS, EMS, and MSS were higher. The TBUT of the symptomatic RA group was significantly less than that of the asymptomatic group, and the CFS was higher. In the active RA group, only the CFS was higher than that of the stable group, and there was no significant difference between the two groups for other parameters. Furthermore, there was no significant correlation between the course of RA and the dry eye ( > 0.05).
The rheumatoid activity does not necessarily lead to an aggravation of dry eye. Regardless of the duration, RA was not found to exhibit relation with the severity of dry eye. . RA patients with disease active period cannot be ignored for the existence of dry eye, since patients with dry eye often lack the signs and symptoms.
本研究调查类风湿关节炎（RA）患者干眼与疾病活动度之间的关系。
根据眼表疾病指数（OSDI）将RA患者分为症状性组（评分≥12）和无症状组（评分＜12）。通过疾病活动度评分（DAS-28）问卷，将他们分为活动组（评分＞2.6）和稳定组（评分≤2.6）。在对照组中，选取20名年龄和性别匹配的健康成年人。对RA患者和健康成年人进行泪膜破裂时间（TBUT）、泪河高度（TMH）、角膜荧光素染色（CFS）、睑板腺扫描（MS）、睑板腺分泌评分（MSS）和睑缘评估（EMS）检查。
RA组的TBUT显著低于对照组，而CFS、MS、EMS和MSS更高。症状性RA组的TBUT显著低于无症状组，且CFS更高。在活动期RA组中，只有CFS高于稳定组，两组其他参数无显著差异。此外，RA病程与干眼之间无显著相关性（＞0.05）。
类风湿活动度不一定导致干眼加重。无论病程长短，未发现RA与干眼严重程度有关。由于干眼患者常缺乏体征和症状，因此不能忽视疾病活动期RA患者存在干眼的情况。
