Luo Chenqi, Chen Xinyi, Jin Hongchuan, Yao Ke
Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Department of Medical Oncology, Key Laboratory of Biotherapy in Zhejiang, Sir Runrun Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China.
PLoS One. 2017 Jun 29;12(6):e0180188. doi: 10.1371/journal.pone.0180188. eCollection 2017.
To evaluate the relationship between gout and age-related cataracts (ARCs).
A comprehensive literature search of the PubMed and Web of Science databases was conducted to identify papers on the association between gout and cataract risk that had been published between February 1991 and January 2017. Pooled relative risks (RRs) or odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated. The random-effects model was used instead of the fixed-effects model when heterogeneity was identified, as indicated by a Cochran's Q statistic P-value <0.10 or I2 index score >50%.
A total of 3 cross-sectional studies and 3 case-control studies were included in the meta-analysis. Gout was significantly associated with increased odds of ARCs (OR 1.53, 95% CI 1.27-1.84). In the subgroup analysis, gout exhibited positive associations with the odds of posterior subcapsular cataracts (PSCs, OR 1.69, 95% CI: 1.06-2.70) and cortical cataracts (CCs, OR 1.39, 95% CI: 1.06-1.81). However, no association was identified between gout and the odds of nuclear cataracts.
The current literature suggested that gout may be associated with increased odds of ARCs, especially PSCs and CCs. Further efforts should be made to confirm these findings and clarify the effect of gout and gout medications on the development of cataracts.
评估痛风与年龄相关性白内障（ARCs）之间的关系。
对PubMed和Web of Science数据库进行全面文献检索，以识别1991年2月至2017年1月期间发表的关于痛风与白内障风险关联的论文。计算合并相对风险（RRs）或比值比（ORs）及其相应的95%置信区间（CIs）。当异质性被识别时，如Cochran's Q统计量P值<0.10或I2指数得分>50%，则使用随机效应模型而非固定效应模型。
荟萃分析共纳入3项横断面研究和3项病例对照研究。痛风与年龄相关性白内障的发病几率显著增加相关（OR 1.53，95% CI 1.27 - 1.84）。在亚组分析中，痛风与后囊下白内障（PSCs，OR 1.69，95% CI：1.06 - 2.70）和皮质性白内障（CCs，OR 1.39，95% CI：1.06 - 1.81）的发病几率呈正相关。然而，未发现痛风与核性白内障的发病几率之间存在关联。
当前文献表明，痛风可能与年龄相关性白内障的发病几率增加有关，尤其是后囊下白内障和皮质性白内障。应进一步努力证实这些发现，并阐明痛风及痛风药物对白内障发生发展的影响。
