First Department of Pediatrics, National and Kapodistrian University of Athens, Choremeio Research Laboratory, Hematology/Oncology Unit, Athens, Greece.
Laboratory of Chemistry, Department of Food Science & Human Nutrition, School of Food Biotechnology and Development, Agricultural University of Athens, Athens, Greece.
Curr Neuropharmacol. 2019;17(4):377-402. doi: 10.2174/1570159X16666180321095705.
Reactive oxygen species and reactive nitrogen species, which are collectively called reactive oxygen-nitrogen species, are the inevitable by-products of cellular metabolic redox reactions, such as oxidative phosphorylation in the mitochondrial respiratory chain, phagocytosis, reactions of biotransformation of exogenous and endogenous substrata in endoplasmic reticulum, eicosanoid synthesis, and redox reactions in the presence of metal with variable valence. Among medicinal plants, there is growing interest in Crocus Sativus L. It is a perennial, stemless herb, belonging to Iridaceae family, cultivated in various countries such as Greece, Italy, Spain, Israel, Morocco, Turkey, Iran, India, China, Egypt and Mexico.
The present study aims to address the protective role of Crocus Sativus L. in neurodegeneration with an emphasis in Parkinson's and Alzheimer's disease.
An electronic literature search was conducted by two of the authors from 1993 to August 2017. Original articles and systematic reviews (with or without meta-analysis), as well as case reports were selected. Titles and abstracts of papers were screened by a third reviewer to determine whether they met the eligibility criteria, and full texts of the selected articles were retrieved.
Hence, the authors focused on the literature concerning the role of Crocus Sativus L. on its anti-oxidant and neuroprotective properties.
Literature findings represented in current review herald promising results for using Crocus Sativus L. and/or its active constituents as antioxidants, anti-inflammatory, and neuroprotective agents.
活性氧和活性氮，统称为活性氧氮，是细胞代谢氧化还原反应的必然副产物，如线粒体呼吸链中的氧化磷酸化、吞噬作用、内质网中外源和内源性底物的生物转化反应、前列腺素合成以及存在可变价金属的氧化还原反应。在药用植物中，藏红花（Crocus sativus L.）越来越受到关注。它是一种多年生、无茎草本植物，属于鸢尾科，在希腊、意大利、西班牙、以色列、摩洛哥、土耳其、伊朗、印度、中国、埃及和墨西哥等国均有种植。
本研究旨在探讨藏红花在神经退行性疾病（尤其是帕金森病和阿尔茨海默病）中的保护作用。
两位作者于 1993 年至 2017 年 8 月进行了电子文献检索。选择了原始文章和系统评价（有或没有荟萃分析）以及病例报告。由第三位审稿人筛选论文的标题和摘要，以确定是否符合入选标准，并检索选定文章的全文。
因此，作者重点关注了藏红花在抗氧化和神经保护特性方面的文献。
当前综述中的文献结果预示着使用藏红花及其活性成分作为抗氧化剂、抗炎剂和神经保护剂具有广阔的前景。
