Hatziagapiou Kyriaki, Lambrou George I
First Department of Pediatrics, National and Kapodistrian University of Athens, Choremeio Research Laboratory, Hematology/ Oncology Unit, Thivon & Levadeias, 11527, Athens, Greece.
Curr Cardiol Rev. 2018;14(4):272-289. doi: 10.2174/1573403X14666180628095918.
Reactive oxygen species and reactive nitrogen species, which are collectively called reactive oxygen-nitrogen species, are inevitable by-products of cellular metabolic redox reactions, such as oxidative phosphorylation in the mitochondrial respiratory chain, phagocytosis, reactions of biotransformation of exogenous and endogenous substrate in endoplasmic reticulum, eicosanoid synthesis, and redox reactions in the presence of metal with variable valence. Among medicinal plants, there is growing interest in Crocus Sativus L. It is a perennial, stemless herb, belonging to Iridaceae family, cultivated in various countries such as Greece, Italy, Spain, Israel, Morocco, Turkey, Iran, India, China, Egypt and Mexico.
The present study aims to address the anti-toxicant role of Crocus Sativus L. in the case of cardiovascular disease and its role towards the cardioprotective role of Crocus Sativus L.
An electronic literature search was conducted by the two authors from 1993 to August 2017. Original articles and systematic reviews (with or without meta-analysis), as well as case reports were selected. Titles and abstracts of papers were screened by a third reviewer to determine whether they met the eligibility criteria, and full texts of the selected articles were retrieved.
Our review has indicated that scientific literature confirms the role of Crocus Sativus L. as a cardiovascular-protective agent. The literature review showed that Saffron is a potent cardiovascular- protective agent with a plethora of applications ranging from ischemia-reperfusion injury, diabetes and hypertension to hyperlipidemia.
Literature findings represented in current review herald promising results for using Crocus Sativus L. and/or its active constituents as a cardiovascular-protective agent and in particular, Crocus Sativus L. manifests beneficial results against ischemia-reperfusion injury, hypertension, hyperlipidemia and diabetes.
活性氧和活性氮统称为活性氧氮物质，是细胞代谢氧化还原反应不可避免的副产物，如线粒体呼吸链中的氧化磷酸化、吞噬作用、内质网中外源和内源性底物的生物转化反应、类花生酸合成以及可变价金属存在下的氧化还原反应。在药用植物中，番红花越来越受到关注。它是一种多年生无茎草本植物，属于鸢尾科，在希腊、意大利、西班牙、以色列、摩洛哥、土耳其、伊朗、印度、中国、埃及和墨西哥等多个国家种植。
本研究旨在探讨番红花在心血管疾病中的抗毒作用及其对心脏保护作用的影响。
两位作者于1993年至2017年8月进行了电子文献检索。选取原始文章、系统评价（有无Meta分析）以及病例报告。由第三位审阅者筛选论文的标题和摘要，以确定它们是否符合纳入标准，并检索所选文章的全文。
我们的综述表明，科学文献证实了番红花作为心血管保护剂的作用。文献综述表明，藏红花是一种有效的心血管保护剂，具有从缺血再灌注损伤、糖尿病、高血压到高脂血症等多种应用。
当前综述中的文献研究结果预示着使用番红花及其活性成分作为心血管保护剂有良好前景，特别是番红花对缺血再灌注损伤、高血压、高脂血症和糖尿病显示出有益效果。
