Mazieiro Rafaela, Frizon Renata Reis, Barbalho Sandra Maria, Goulart Ricardo de Alvares
1 Department of Biochemistry and Pharmacology, Medical School of Marília, UNIMAR, Marília , São Paulo, Brazil .
2 Department of Biochemistry and Nutrition, Food Technology School , Marília, São Paulo, Brazil .
J Med Food. 2018 Nov;21(11):1077-1085. doi: 10.1089/jmf.2017.0146. Epub 2018 Jun 29.
The inflammatory bowel diseases (IBDs) are mainly represented by Crohn's disease and Ulcerative colitis that are characterized by chronic and relapsing inflammatory processes of the gastrointestinal system. Curcuma longa L. is a plant with several medicinal properties, including anti-inflammatory effects, and curcumin is the most important compound derived from its rhizomes. As curcumin has remarkable anti-inflammatory actions, the aim of this work is to review the potential use of this compound in IBD patients. We consulted MEDLINE (PubMed/PMC), and the literature search was performed with the following combinations of terms "Inflammatory Bowel Diseases" and "Curcumin," "Crohn's Disease" and "Curcumin," "Ulcerative colitis" and "Curcumin." The inclusion criteria were articles that showed original studies with human models and the exclusion criteria were not full-text articles, articles not in English, poster presentations, letters, editorials, and articles not available. Curcumin interacts with receptors, growth and transcription factors, cytokines, enzymes, and genes leading to inhibitory effects on cyclooxygenase-1, tumor necrosis factor-α, interferon-γ, inducible nitric oxide synthase, transcriptional nuclear factor kappa B, and many other molecules associated with inflammatory processes. These molecules are critical factors in the positive regulation of inflammatory cytokines in inflammatory diseases, suggesting that curcumin may be considered as a new therapeutic agent for patients with IBD. Curcumin is a natural anti-inflammatory agent that represents an attractive, safe and inexpensive alternative for the treatment of IBD. Nevertheless, it is necessary to know the efficient and safe dose and consider its poor absorption.
炎症性肠病（IBD）主要包括克罗恩病和溃疡性结肠炎，其特征为胃肠道系统的慢性复发性炎症过程。姜黄是一种具有多种药用特性的植物，包括抗炎作用，姜黄素是从其根茎中提取的最重要的化合物。由于姜黄素具有显著的抗炎作用，本研究旨在综述该化合物在IBD患者中的潜在应用。我们查阅了MEDLINE（PubMed/PMC），并使用以下术语组合进行文献检索：“炎症性肠病”和“姜黄素”、“克罗恩病”和“姜黄素”、“溃疡性结肠炎”和“姜黄素”。纳入标准为展示人体模型原始研究的文章，排除标准为非全文文章、非英文文章、海报展示、信函、社论以及无法获取的文章。姜黄素与受体、生长和转录因子、细胞因子、酶及基因相互作用，对环氧合酶-1、肿瘤坏死因子-α、干扰素-γ、诱导型一氧化氮合酶、转录核因子κB以及许多其他与炎症过程相关的分子产生抑制作用。这些分子是炎症性疾病中炎症细胞因子正调控的关键因素，提示姜黄素可被视为IBD患者的一种新型治疗药物。姜黄素是一种天然抗炎剂，是治疗IBD的一种有吸引力、安全且廉价的替代药物。然而，有必要了解其有效且安全的剂量，并考虑其吸收较差的问题。
