Department of Pharmacy, National Hospital Organization Beppu Medical Center , Beppu, Japan .
J Palliat Med. 2018 May;21(5):598-603. doi: 10.1089/jpm.2017.0585. Epub 2018 Mar 22.
The skin fixative used in Mohs chemosurgery contains zinc chloride and is referred to as Mohs paste (MP). However, MP shows a remarkable change in rheological characteristics after its preparation.
To prepare an MP with stable rheological characteristics, we prepared a modified MP (mMP) using zinc oxide 10% single ointment (Zn), which is an oil-based ointment.
We evaluated mMP by determining its rheological characteristics, depth of tissue fixation, and observation of the tissue surface after treatment.
The viscosity of mMP increased after three months. However, the treatment-dependent viscosity of mMP could be obtained by mixing with glycerin. The viscosity and spreadability of mMP, which was three months after preparation, were 1992.0 ± 376.5 Pa·s and 2.1 ± 0.1 cm, respectively. In contrast, the viscosity and spreadability of MP mixed with glycerin were 436.9 ± 0.0 Pa·s and 2.8 ± 0.0 cm, respectively. The fixed invasion depth of MP was significantly higher than that of mMP (p < 0.05).
This study of a mixture of MP and Zn showed that the viscosity of mMP could be adjusted with glycerin. Also, the tissue fixation of mMP progressed slowly compared with that of MP. This finding suggests that mMP is effective and safe for Mohs treatment.
Mohs 化学外科中使用的皮肤固定剂含有氯化锌，称为 Mohs 糊剂（MP）。然而，MP 在制备后其流变特性会发生显著变化。
为了制备具有稳定流变特性的 MP，我们使用 10%氧化锌单软膏（Zn），即油基软膏，制备了改良的 MP（mMP）。
我们通过测定 mMP 的流变特性、组织固定深度以及治疗后组织表面的观察来评估 mMP。
mMP 的粘度在三个月后增加。然而，通过与甘油混合可以获得 mMP 的治疗依赖性粘度。制备三个月后的 mMP 的粘度和铺展性分别为 1992.0±376.5 Pa·s 和 2.1±0.1 cm。相比之下，与甘油混合的 MP 的粘度和铺展性分别为 436.9±0.0 Pa·s 和 2.8±0.0 cm。MP 的固定侵入深度明显高于 mMP（p<0.05）。
本研究对 MP 和 Zn 的混合物进行了研究，表明 mMP 的粘度可以用甘油来调节。此外，mMP 的组织固定速度比 MP 慢。这一发现表明 mMP 对于 Mohs 治疗是有效且安全的。
